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3.1.-.- Ester bond enzymes

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

3199
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galactosamine (N-acetyl)-6-sulfatase Show summary » More detailed page go icon to follow link

palmitoyl-protein thioesterase 1 Show summary »


Target Id 3199
Nomenclature palmitoyl-protein thioesterase 1
Genes PPT1 (Hs), Ppt1 (Mm), Ppt1 (Rn)
EC number
3.1.2.22
Removes thioester-linked fatty acyl groups (e.g. palmitate) from modified cysteine residues in proteins/peptides during lysosomal degradation. Prefers acyl chain lengths of 14-18 carbons H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H+ + hexadecanoate + L-cysteinyl-[protein] [3]
Inhibitors
ezurpimtrostat [2]
Comment Involved in the catabolism of lipid-modified proteins during lysosomal degradation and autophagy. Inhibitors of PPT1 enzyme activity disrupt lysosomal function and autophagy, and are being examined for antitumour potential [2] and antiviral activity against SARS-CoV-2 [1].

References

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How to cite this family page

Database page citation:

3.1.-.- Ester bond enzymes. Accessed on 29/06/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=880.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.