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R4 family C

Formerly known as: B family of RGS proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The R4 family of RGS proteins is the largest family of RGS proteins with 10 members. Each of the R4 family members contain only small N- and C-termini apart from the RGS domain. The N-terminal amphipathic helix present in most R4 family members serves an important function in membrane association and can directly bind phospholipids. In contrast to the RGS domain, which is well conserved among members of the R4 family of RGS proteins, the N- and C-termini vary, enabling specificity of non-GAP functions. Despite the non-complex structure of these proteins, several R4 family RGS proteins have been shown to possess additional functions apart from acting as GAPs at activated Gα subunits [1,3].

Targets

RGS1 (regulator of G-protein signaling 1) C Show summary » More detailed page

RGS2 (regulator of G-protein signaling 2) C Show summary » More detailed page

RGS3 (regulator of G-protein signaling 3) C Show summary » More detailed page

RGS4 (regulator of G-protein signaling 4) C Show summary » More detailed page

RGS5 (regulator of G-protein signaling 5) C Show summary » More detailed page

RGS8 (regulator of G-protein signaling 8) C Show summary » More detailed page

RGS13 (regulator of G-protein signaling 13) C Show summary » More detailed page

RGS16 (regulator of G-protein signaling 16) C Show summary » More detailed page

RGS18 (regulator of G-protein signaling 18) C Show summary » More detailed page

RGS21 (regulator of G-protein signaling 21) C Show summary » More detailed page

Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.