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Protein tyrosine phosphatases non-receptor type (PTPN)

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Protein tyrosine phosphatases (PTPs) catalyse the hydrolysis of phosphate monoesters on tyrosine residues, in opposition to tyrosine kinase-catalysed phosphorylation.
The HGNC lists 17 members in the 'Protein tyrosine phosphatases, non-receptor type (PTPN)' family (ID 812).

Enzymes

3255
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PTP1B (protein tyrosine phosphatase non-receptor type 1) Show summary » More detailed page go icon to follow link

protein tyrosine phosphatase non-receptor type 2 Show summary »


Target Id 3255
Nomenclature protein tyrosine phosphatase non-receptor type 2
Previous and unofficial names PTPT | TC-PTP | TCPTP | T-cell protein-tyrosine phosphatase
Genes PTPN2 (Hs), Ptpn2 (Mm), Ptpn2 (Rn)
Ensembl ID ENSG00000175354 (Hs), ENSMUSG00000024539 (Mm)
UniProtKB AC P17706 (Hs), Q06180 (Mm)
EC number
3.1.3.48
Inhibitors
compound 182 [PMID: 37500611] pKi 9.6 [3]
compound 182 [PMID: 37500611] pIC50 9.2 [3]
Comment Participates in regulating the JAK-Stat pathway, and T cell receptor and cytokine signalling. Inhibition of PTPN1/2 promotes anti-tumour immunity [1,3,7].

SHP2 (protein tyrosine phosphatase non-receptor type 11) Show summary » More detailed page go icon to follow link

LYP (protein tyrosine phosphatase non-receptor type 22 / PTPN22) Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

Protein tyrosine phosphatases non-receptor type (PTPN). Accessed on 17/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=980.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.