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Immunoglobulin like domain containing proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Targets

3190
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RAGE (advanced glycosylation end-product specific receptor) Show summary » More detailed page go icon to follow link

FcαRI (Fc fragment of IgA receptor / CD89) Show summary » More detailed page go icon to follow link

Fc fragment of IgG receptor IIa Show summary »


Target Id 3190
Nomenclature Fc fragment of IgG receptor IIa
Previous and unofficial names Fc gamma receptor IIa | FcγRIIA | Fcgr3 | Fcgr3a | Immunoglobulin G Fc receptor II | CD32a
Genes FCGR2A (Hs), Fcgr3 (Mm), Fcgr2a (Rn)
Ensembl ID ENSG00000143226 (Hs), ENSMUSG00000059498 (Mm), ENSRNOG00000046663 (Rn)
UniProtKB AC P12318 (Hs), P27645 (Rn)
Comment Serum from patients with vaccine-induced immune thrombocytopenia and thrombosis (VITT; a serious but very rare adverse response to a chimpanzee adenovirus-based SARS-CoV-2 vaccine [2,7]) activates platelets via the FCGR2A (FcγRIIA) [8]. VITT can be managed with intravenous Ig infusion or plasma exchange, but these are expensive and limited resources. In vitro, pharmacological blockade of FcγRIIA-mediated platelet activation can be achieved by drugs that inhibit the function of COX enzymes, P2Y12, or the Src, Syk and BTK kinases. This indicates that small molecules may have clinical potential as VITT therapies.

Fc fragment of IgG receptor IIIa / CD16A Show summary » More detailed page go icon to follow link

FcμRI (Fc fragment of IgM receptor) Show summary » More detailed page go icon to follow link

MALT1 paracaspase Show summary » More detailed page go icon to follow link

CD155 (PVR cell adhesion molecule) Show summary » More detailed page go icon to follow link

TIGIT Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

Immunoglobulin like domain containing proteins. Accessed on 01/12/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=984.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.