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STAT transcription factors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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STAT family transcription factor proteins are phosphorylated by receptor kinases that are the receptors for cytokines and growth factors. Homo- or heterodimer phospho-STATs then translocate to the nucleus to regulate transcription of responsive genes.

Targets

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STAT3 (signal transducer and activator of transcription 3) Show summary » More detailed page go icon to follow link

STAT6 (signal transducer and activator of transcription 6) Show summary » More detailed page go icon to follow link

How to cite this family page

Database page citation:

STAT transcription factors. Accessed on 11/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=990.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.