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STAT transcription factors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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STAT family transcription factor proteins are phosphorylated by receptor kinases that are the receptors for cytokines and growth factors. Homo- or heterodimer phospho-STATs then translocate to the nucleus to regulate transcription of responsive genes.

Targets

3221
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STAT3 (signal transducer and activator of transcription 3) Show summary » More detailed page go icon to follow link

signal transducer and activator of transcription 5A Show summary »


Target Id 3221
Nomenclature signal transducer and activator of transcription 5A
Genes STAT5A (Hs), Stat5a (Mm), Stat5a (Rn)
Ensembl ID ENSG00000126561 (Hs), ENSMUSG00000004043 (Mm), ENSRNOG00000019496 (Rn)
UniProtKB AC P42229 (Hs), P42230 (Mm), Q62771 (Rn)
Ligands
AK-2292 (Binding) pKi 6.7 [1]
Comment A transcription factor of the JAK-STAT signaling network that regulates the cellular response to cytokines.

STAT6 (signal transducer and activator of transcription 6) Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

STAT transcription factors. Accessed on 22/02/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=990.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.