Neuropilins and Plexins

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Neuropilins and Plexins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Neuropilins act as receptors for class 3 (secreted) semaphorins; Plexins are receptors for class 4, 5 and 6 (transmembrane) semaphorins and are signalling partners for class 3 semaphorins. The semaphorins and their receptors participate in numerous and diverse biological processes including neural development, immunology/inflammation, cardiac growth, vascular development, lung morphogenesis, and axial bone patterning.

Targets

neuropilin 1 Show summary »« Hide summary More detailed page go icon to follow link

plexin D1 Show summary »« Hide summary

Target Id

3299

Nomenclature

plexin D1

Genes

PLXND1 (Hs), Plxnd1 (Mm), Plxnd1 (Rn)

Ensembl ID

ENSG00000004399 (Hs), ENSMUSG00000030123 (Mm), ENSRNOG00000025209 (Rn)

UniProtKB AC

Q9Y4D7 (Hs), Q3UH93 (Mm)

Inhibitors

D1SP [1]

Comment

PlexinD1 is a semaphorin receptor that participates in axon guidance. Upregulation of PlexinD1 expression (and of its ligands Sema3E and Sema3C) acts to drive aggressiveness, invasiveness, and drug resistance in metastatic prostate cancer cells [1]. A synthetic PlexinD1:Fc decoy fusion protein (D1SP) has been demonstrated to suppress prostate cancer proliferation in preclinical models.

References

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How to cite this family page

Database page citation:

Neuropilins and Plexins. Accessed on 03/04/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=991.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Cidlowski JA, Davenport AP, Fabbro D, Spedding M, Striessnig J, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets. Br J Pharmacol. 182: S1-S23.