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Neuropilins and Plexins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Neuropilins act as receptors for class 3 (secreted) semaphorins; Plexins are receptors for class 4, 5 and 6 (transmembrane) semaphorins and are signalling partners for class 3 semaphorins. The semaphorins and their receptors participate in numerous and diverse biological processes including neural development, immunology/inflammation, cardiac growth, vascular development, lung morphogenesis, and axial bone patterning.


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How to cite this family page

Database page citation:

Neuropilins and Plexins. Accessed on 29/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.