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2.7.1.40 Pyruvate kinases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

3007
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pyruvate kinase M1/2 Show summary » More detailed page go icon to follow link

pyruvate kinase L/R Show summary »


Target Id 3007
Nomenclature pyruvate kinase L/R
Genes PKLR (Hs), Pklr (Mm), Pklr (Rn)
Ensembl ID ENSG00000143627 (Hs), ENSMUSG00000041237 (Mm), ENSRNOG00000020420 (Rn)
UniProtKB AC P30613 (Hs), P12928 (Rn)
EC number
2.7.1.40
ATP + pyruvate <=> ADP + phosphoenolpyruvate
Comment The protein products of the PKLR gene are isozymes that catalyse the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP. This activity is the rate-limiting step of glycolysis.

How to cite this family page

Database page citation:

2.7.1.40 Pyruvate kinases. Accessed on 17/05/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=994.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.