Top ▲

Pyruvate kinases (EC

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


Click here for help

pyruvate kinase M1/2 Show summary » More detailed page go icon to follow link

pyruvate kinase L/R Show summary »

Target Id 3007
Nomenclature pyruvate kinase L/R
Genes PKLR (Hs), Pklr (Mm), Pklr (Rn)
Ensembl ID ENSG00000143627 (Hs), ENSMUSG00000041237 (Mm), ENSRNOG00000020420 (Rn)
UniProtKB AC P30613 (Hs), P12928 (Rn)
EC number
ATP + pyruvate <=> ADP + phosphoenolpyruvate
Allosteric modulators
etavopivat (Positive) pEC50 6.9 [2]
mitapivat (Positive) [1]
Comment The protein products of the PKLR gene are isozymes that catalyse the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP. This activity is the rate-limiting step of glycolysis.


Click here for help

Show »

How to cite this family page

Database page citation:

Pyruvate kinases (EC Accessed on 04/03/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.