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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
BCL3 transcription coactivator Show summary » |
IκBζ (NFKB inhibitor zeta)
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Database page citation:
Inhibitors of NF-kappaB (IκB) family proteins. Accessed on 03/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=996.
Concise Guide to PHARMACOLOGY citation:
Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. Br J Pharmacol. 178 Suppl 1:S1-S26.
IκB proteins are components of the regulatory network that controls activation (or inhibition) of the NF-κB transcription factors that play crucial roles in inflammation, immunity, cell proliferation and apoptosis [5]. The IκB proteins can be divided into two distinct groups, the classical (cytoplasmic) and the atypical (nuclear) IκB proteins.