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interleukin-17D   Click here for help

GtoPdb Ligand ID: 14474

Synonyms: IL-17D
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-17D is expressed in skeletal muscle, heart, and adipose tissue. In endothelial cells it induces expression of pro-inflammatory cytokines IL-6, IL-8 (CXCL8) and GM-CSF (CSF2) via the NF-κB and MAPK signaling pathways. A functional receptor for IL-17D is proposed to be CD93 (UniProt entry Q8TAD2; CD93) [1-3].
Species: Human
Immunopharmacology Comments
Involved in regulating immune responses against tumours and viral/bacterial infections; linked to autoimmune conditions.