interleukin-17D

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Ligands
interleukin-17D (Human)

GtoPdb Ligand ID: 14474

Synonyms: IL-17D

Compound class: Endogenous peptide in human, mouse or rat

Comment: IL-17D is expressed in skeletal muscle, heart, and adipose tissue. In endothelial cells it induces expression of pro-inflammatory cytokines IL-6, IL-8 (CXCL8) and GM-CSF (CSF2) via the NF-κB and MAPK signaling pathways. A functional receptor for IL-17D is proposed to be CD93 (UniProt entry Q8TAD2; CD93) [1-3].

Species: Human

References
1. Huang J, Lee HY, Zhao X, Han J, Su Y, Sun Q, Shao J, Ge J, Zhao Y, Bai X et al.. (2021) Interleukin-17D regulates group 3 innate lymphoid cell function through its receptor CD93. Immunity, 54 (4): 673-686.e4. [PMID:33852831]
2. Jiang K, Xu Y, Wang Y, Yin N, Huang F, Chen M. (2025) Deciphering the role of IL-17D, its newly identified receptor CD93, and IL-17D-CD93 axis in health and disease. J Immunol, 214 (6): 1113-1122. [PMID:40258301]
3. Shi S, Zhang J, Pan Y, Liu X, Zeng R, Xu C, Wang Y, Qi Q, Guo Z, Yao C et al.. (2025) Interleukin-17D Attenuates OVA-induced Airway Inflammation and Remodeling Partially via the CD93 Receptor. Allergy Asthma Immunol Res, 17 (5): 592-614. [PMID:41044834]

References

1. Huang J, Lee HY, Zhao X, Han J, Su Y, Sun Q, Shao J, Ge J, Zhao Y, Bai X et al.. (2021)
Interleukin-17D regulates group 3 innate lymphoid cell function through its receptor CD93.
Immunity, 54 (4): 673-686.e4. [PMID:33852831]

2. Jiang K, Xu Y, Wang Y, Yin N, Huang F, Chen M. (2025)
Deciphering the role of IL-17D, its newly identified receptor CD93, and IL-17D-CD93 axis in health and disease.
J Immunol, 214 (6): 1113-1122. [PMID:40258301]

3. Shi S, Zhang J, Pan Y, Liu X, Zeng R, Xu C, Wang Y, Qi Q, Guo Z, Yao C et al.. (2025)
Interleukin-17D Attenuates OVA-induced Airway Inflammation and Remodeling Partially via the CD93 Receptor.
Allergy Asthma Immunol Res, 17 (5): 592-614. [PMID:41044834]