sFRP-3

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Ligands
sFRP-3 (Human)

GtoPdb Ligand ID: 3693

Synonyms: Frezzled | Frizzled-related protein 1 | secreted Frizzled-related protein 3

Compound class: Endogenous peptide in human, mouse or rat

Comment: This peptide is encoded by the FRZB gene. It acts as a Wnt signaling antagonist that is expressed in chondrocytes and functions in bone development [1].

Species: Human

Summary
Biological activity
References
Structure

References
1. Oldefest M, Düsterhöft S, Desel C, Thysen S, Fink C, Rabe B, Lories R, Grötzinger J, Lorenzen I. (2015) Secreted Frizzled-related protein 3 (sFRP3)-mediated suppression of interleukin-6 receptor release by A disintegrin and metalloprotease 17 (ADAM17) is abrogated in the osteoarthritis-associated rare double variant of sFRP3. Biochem J, 468 (3): 507-18. [PMID:25846075]

References

1. Oldefest M, Düsterhöft S, Desel C, Thysen S, Fink C, Rabe B, Lories R, Grötzinger J, Lorenzen I. (2015)
Secreted Frizzled-related protein 3 (sFRP3)-mediated suppression of interleukin-6 receptor release by A disintegrin and metalloprotease 17 (ADAM17) is abrogated in the osteoarthritis-associated rare double variant of sFRP3.
Biochem J, 468 (3): 507-18. [PMID:25846075]