Gene and Protein Information
class A G protein-coupled receptor: pseudogene in man but functional in rodents
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	-	6q23.2	TAAR4P	trace amine associated receptor 4, pseudogene
Mouse	7	347	10 A4	Taar4	trace amine-associated receptor 4
Rat	7	347	1p12	Taar4	trace amine-associated receptor 4

Previous and Unofficial Names

trace amine receptor 4 | trace amine-associated receptor 4

Database Links
Specialist databases
GPCRdb	taar4_mouse (Mm), taar4_rat (Rn)
Other databases
Alphafold	Q5QD15 (Mm), Q923Y7 (Rn)
Ensembl Gene	ENSG00000237449 (Hs), ENSMUSG00000069707 (Mm), ENSRNOG00000029877 (Rn)
Entrez Gene	503612 (Hs), 209513 (Mm), 294122 (Rn)
Human Protein Atlas	ENSG00000237449 (Hs)
KEGG Gene	hsa:503612 (Hs), mmu:209513 (Mm), rno:294122 (Rn)
RefSeq Nucleotide	NM_001008499 (Mm), NM_175583 (Rn)
RefSeq Protein	NP_001008499 (Mm), NP_783173 (Rn)
UniProtKB	Q5QD15 (Mm), Q923Y7 (Rn)
Wikipedia	TAAR4P (Hs)

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference β-phenylethylamine Mm Agonist 6.0 pEC50 1 ⤷ pEC50 6.0 (EC50 1x10-6 M) [1] xylometazoline Mm Full agonist - - 3 ⤷ [3] β-phenylethylamine Rn Partial agonist - - 3 ⤷ [3] naphazoline Mm Agonist - - 3 ⤷ [3] naphazoline Rn Partial agonist - - 3 ⤷ [3]
View species-specific agonist tables
Agonist Comments
Agonist activity for β-phenylethylamine, naphazoline and xylometazoline was measured by CRE-SEAP reporter gene assay [3].

Primary Transduction Mechanisms
Transducer	Effector/Response
Gs family	Adenylyl cyclase stimulation
References:  3

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

General Comments
The compound β-phenylethylamine is elevated in urine in stress responses in rodents and humans, suggesting a role for TAAR4 in stress and social cues [1-2].