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aldehyde dehydrogenase 5 family member A1

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Target not currently curated in GtoImmuPdb

Target id: 2466

Nomenclature: aldehyde dehydrogenase 5 family member A1

Abbreviated Name: SSADH

Family: GABA turnover

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 535 6p22.3 ALDH5A1 aldehyde dehydrogenase 5 family member A1
Mouse - 523 13 10.77 cM Aldh5a1 aldhehyde dehydrogenase family 5, subfamily A1
Rat - 523 17p11 Aldh5a1 aldehyde dehydrogenase 5 family, member A1
Previous and Unofficial Names Click here for help
NAD(+)-dependent succinic semialdehyde dehydrogenase | SSADH, SSDH | succinate-semialdehyde dehydrogenase, mitochondrial | aldehyde dehydrogenase 5 family, member A1 | aldehyde dehydrogenase 5 family | aldhehyde dehydrogenase family 5, subfamily A1 | aldhehyde dehydrogenase family 5
Database Links Click here for help
Alphafold P51649 (Hs), Q8BWF0 (Mm), G3V945 (Rn)
BRENDA 1.2.1.24
CATH/Gene3D 3.40.605.10
ChEMBL Target CHEMBL1911 (Hs)
Ensembl Gene ENSG00000112294 (Hs), ENSMUSG00000035936 (Mm), ENSRNOG00000023538 (Rn)
Entrez Gene 7915 (Hs), 214579 (Mm), 291133 (Rn)
Human Protein Atlas ENSG00000112294 (Hs)
KEGG Enzyme 1.2.1.24
KEGG Gene hsa:7915 (Hs), mmu:214579 (Mm), rno:291133 (Rn)
OMIM 610045 (Hs)
Pharos P51649 (Hs)
RefSeq Nucleotide NM_001080 (Hs), NM_170740 (Hs), NM_172532 (Mm), NM_022851 (Rn)
RefSeq Protein NP_733936 (Hs), NP_001071 (Hs), NP_766120 (Mm), NP_074042 (Rn)
UniProtKB P51649 (Hs), Q8BWF0 (Mm), G3V945 (Rn)
Wikipedia ALDH5A1 (Hs)
Enzyme Reaction Click here for help
EC Number: 1.2.1.24 4-Oxobutanoate + NAD + H2O = succinic acid + NADH + 2H+
4-hydroxy-trans-2-nonenal + NAD + H2O = 4-hydroxy-trans-2-nonenoate + NADH + 2H+
Cofactors Click here for help
Cofactor Species Comments Reference
NAD None

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
4-acryloylphenol Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 6.5 pIC50 1
⤷ pIC50 6.5 (IC50 3.5x10-7 M) [1]
Inhibitor Comments
This enzyme is inhibited by the approved drug valproic acid.
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Succinic semialdehyde dehydrogenase deficiency; SSADHD
Synonyms: 4-hydroxybutyric aciduria [Orphanet: ORPHA22]
Disease Ontology: DOID:0060175
OMIM: 271980
Orphanet: ORPHA22

References

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1. Tao YH, Yuan Z, Tang XQ, Xu HB, Yang XL. (2006) Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg Med Chem Lett, 16 (3): 592-5. [PMID:16290145]

How to cite this page

GABA turnover: aldehyde dehydrogenase 5 family member A1. Last modified on 29/01/2016. Accessed on 29/10/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2466.