Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	4	412	17q25.1	ZACN	zinc activated ion channel	1-2

Previous and Unofficial Names

ZAC1 | LGICZ1 | L2 | LGICZ | zinc activated ligand-gated ion channel

Database Links
Alphafold	Q401N2 (Hs)
CATH/Gene3D	2.70.170.10
Ensembl Gene	ENSG00000186919 (Hs)
Entrez Gene	353174 (Hs)
Human Protein Atlas	ENSG00000186919 (Hs)
KEGG Gene	hsa:353174 (Hs)
OMIM	610935 (Hs)
Pharos	Q401N2 (Hs)
RefSeq Nucleotide	NM_180990 (Hs)
RefSeq Protein	NP_851321 (Hs)
UniProtKB	Q401N2 (Hs)
Wikipedia	ZACN (Hs)

Functional Characteristics
Outwardly rectifying current (both constitutive and evoked by Zn2+)

Ion Selectivity and Conductance Comments

ZAC is cation-selective [1]

Natural/Endogenous Ligands
Cu2+
H+
Zn2+

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference H+ Hs Agonist 5.6 pEC50 4 ⤷ pEC50 5.6 [4] Cu2+ Hs Agonist 5.4 pEC50 4 ⤷ pEC50 5.4 [4] Zn2+ Hs Agonist 3.3 – 3.7 pEC50 1,4 ⤷ pEC50 3.3 – 3.7 [1,4]
Agonist Comments
ZAC is spontaneously active and mediates an outwardly rectifying conductance. In whole cell recordings, the spontaneous current increases in magnitude with time [1]. The magnitude of the Zn2+-activated current does not correlate with that of the spontaneous current [1].

Antagonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference tubocurarine Hs Antagonist 5.2 pIC50 1 ⤷ pIC50 5.2 (IC50 6.3x10-6 M) [1] Ca2+ Hs Antagonist 2.0 pIC50 4 ⤷ pIC50 2.0 [4]
Antagonist Comments
(+)-Tubocurarine (100 μM) also blocks spontaneous currents mediated by ZAC [1]. Although tabulated as an antagonist, it remains possible that (+)-tubocurarine acts as a channel blocker.

Allosteric Modulators
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Voltage-dependent (mV) Reference TTFB Hs Antagonist 5.5 pIC50 - no 3 ⤷ pIC50 5.5 [3] Not voltage dependent

Tissue Distribution
Prostate, thyroid, trachea, fetal whole brain, spinal cord, placenta, stomach. Species:  Human Technique:  RT-PCR References:  1
Adult brain, pancreas, liver, lung, heart, kidney, skeletal muscle. Species:  Human Technique:  cDNA PCR amplification References:  2

General Comments

The ZAC subunit does not appear to exist in the mouse or rat genomes [1]. Although tabulated as an antagonist, it is possible that acts as a channel blocker. Antagonism by Ca2+ is voltage-independent. ZAC is not activated (at 1 mM) by transition metals including Fe2+, Co2+, Ni2+, Cd2+, or Al3+ [4]. The concentration response relationship to Cu2+ is biphasic, with concentrations exceeding 30 μM being associated with reduced activation [4].