HPGD | Prostaglandin synthases | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 1384

Nomenclature: HPGD

Family: Prostaglandin synthases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - HPGD 15-hydroxyprostaglandin dehydrogenase
Mouse - - Hpgd hydroxyprostaglandin dehydrogenase 15 (NAD)
Rat - - Hpgd 15-hydroxyprostaglandin dehydrogenase
Previous and Unofficial Names
15-hydroxyprostaglandin dehydrogenase (NAD)  | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 15-PGDH | PGDH | prostaglandin dehydrogenase 1 | hydroxyprostaglandin dehydrogenase 15-(NAD) | hydroxyprostaglandin dehydrogenase 15 (NAD)
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
Enzyme Reaction
EC Number:
Description Reaction Reference
15-hydroxyprostaglandins => 15-ketoprostaglandins
LXA4 => 15-keto-lipoxin A4 1

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 3 [PMID: 21650226] Hs Inhibition 8.1 pIC50 2
pIC50 8.1 (IC50 8x10-9 M) [2]


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1. Maddox JF, Serhan CN. (1996) Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction. J. Exp. Med., 183 (1): 137-46. [PMID:8551217]

2. Wu Y, Karna S, Choi CH, Tong M, Tai HH, Na DH, Jang CH, Cho H. (2011) Synthesis and biological evaluation of novel thiazolidinedione analogues as 15-hydroxyprostaglandin dehydrogenase inhibitors. J. Med. Chem., 54 (14): 5260-4. [PMID:21650226]


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