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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 663 | 17p13.1 | ALOX12 | arachidonate 12-lipoxygenase, 12S type | |
Mouse | - | 663 | 11 42.99 cM | Alox12 | arachidonate 12-lipoxygenase | |
Rat | - | 663 | 10q24 | Alox12 | arachidonate 12-lipoxygenase, 12S type |
Previous and Unofficial Names ![]() |
arachidonate 12-lipoxygenase, 12S-type | platelet-type lipoxygenase 12 | arachidonate 12-lipoxygenase, 12S type |
Database Links ![]() |
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Alphafold | P18054 (Hs), P39655 (Mm), F1LQ70 (Rn) |
BRENDA | 1.13.11.31 |
CATH/Gene3D | 2.60.60.20 |
ChEMBL Target | CHEMBL3687 (Hs), CHEMBL3225 (Mm) |
Ensembl Gene | ENSG00000108839 (Hs), ENSMUSG00000000320 (Mm), ENSRNOG00000027037 (Rn) |
Entrez Gene | 239 (Hs), 11684 (Mm), 287454 (Rn) |
Human Protein Atlas | ENSG00000108839 (Hs) |
KEGG Enzyme | 1.13.11.31 |
KEGG Gene | hsa:239 (Hs), mmu:11684 (Mm), rno:287454 (Rn) |
OMIM | 152391 (Hs) |
Pharos | P18054 (Hs) |
UniProtKB | P18054 (Hs), P39655 (Mm), F1LQ70 (Rn) |
Wikipedia | ALOX12 (Hs) |
Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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1. Luci DK, Jameson 2nd JB, Yasgar A, Diaz G, Joshi N, Kantz A, Markham K, Perry S, Kuhn N, Yeung J et al.. (2014) Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. J Med Chem, 57 (2): 495-506. [PMID:24393039]