12S-LOX | Lipoxygenases | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 1387

Nomenclature: 12S-LOX

Family: Lipoxygenases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - ALOX12 arachidonate 12-lipoxygenase, 12S type
Mouse - - Alox12 arachidonate 12-lipoxygenase
Rat - - Alox12 arachidonate 12-lipoxygenase
Previous and Unofficial Names
arachidonate 12-lipoxygenase, 12S-type | platelet-type lipoxygenase 12 | arachidonate 12-lipoxygenase, 12S type
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
Enzyme Reaction
EC Number:
Description Reaction Reference
Arachidonic acid + O2 => 12S-HPETE

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ML355 Hs Inhibition 6.5 pIC50 1
pIC50 6.5 (IC50 3.4x10-7 M) [1]


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1. Luci DK, Jameson 2nd JB, Yasgar A, Diaz G, Joshi N, Kantz A, Markham K, Perry S, Kuhn N, Yeung J et al.. (2014) Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. J. Med. Chem., 57 (2): 495-506. [PMID:24393039]


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How to cite this page

Angelo A. Izzo.
Lipoxygenases: 12S-LOX. Last modified on 04/03/2019. Accessed on 18/09/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1387.