Dipeptidase 1 | M19: Membrane dipeptidase | IUPHAR/BPS Guide to PHARMACOLOGY

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Dipeptidase 1

Target not currently curated in GtoImmuPdb

Target id: 1393

Nomenclature: Dipeptidase 1

Family: M19: Membrane dipeptidase, Leukotriene and lipoxin metabolism

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 411 16q24 DPEP1 dipeptidase 1
Mouse - 410 8 E1 Dpep1 dipeptidase 1
Rat - 410 19q12 Dpep1 dipeptidase 1
Previous and Unofficial Names
microsomal dipeptidase | MBD | dipeptidase 1 (renal)
Database Links
Specialist databases
MEROPS M19.001 (Hs)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: LTD4 + H2O = LTE4 + glycine

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
cilastatin ? Inhibition 6.0 pKi 1
pKi 6.0 (Ki 1.1x10-6 M) [1]


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1. Graham DW, Ashton WT, Barash L, Brown JE, Brown RD, Canning LF, Chen A, Springer JP, Rogers EF. (1987) Inhibition of the mammalian beta-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-(acylamino)-3-substituted-propenoic acids. J. Med. Chem., 30 (6): 1074-90. [PMID:3495664]

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