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Dipeptidase 1

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Target not currently curated in GtoImmuPdb

Target id: 1393

Nomenclature: Dipeptidase 1

Family: M19: Membrane dipeptidase, Leukotriene and lipoxin metabolism

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 411 16q24.3 DPEP1 dipeptidase 1
Mouse - 410 8 72.08 cM Dpep1 dipeptidase 1
Rat - 410 19q12 Dpep1 dipeptidase 1
Previous and Unofficial Names Click here for help
microsomal dipeptidase | MBD | dipeptidase 1 (renal)
Database Links Click here for help
Specialist databases
MEROPS M19.001 (Hs)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number: LTD4 + H2O = LTE4 + glycine

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
cilastatin Small molecule or natural product Approved drug Primary target of this compound ? Inhibition 6.0 pKi 1
pKi 6.0 (Ki 1.1x10-6 M) [1]


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1. Graham DW, Ashton WT, Barash L, Brown JE, Brown RD, Canning LF, Chen A, Springer JP, Rogers EF. (1987) Inhibition of the mammalian beta-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-(acylamino)-3-substituted-propenoic acids. J Med Chem, 30 (6): 1074-90. [PMID:3495664]

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