Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	465	6p21.31	STK38	serine/threonine kinase 38
Mouse	-	465	17 A3.3	Stk38	serine/threonine kinase 38
Rat	-	204	20p12	Stk38	serine/threonine kinase 38

Previous and Unofficial Names

nuclear Dbf2-related kinase 1 | Ndr1

Database Links
Alphafold	Q15208 (Hs), Q91VJ4 (Mm)
BRENDA	2.7.11.1
ChEMBL Target	CHEMBL1075155 (Hs)
Ensembl Gene	ENSG00000112079 (Hs), ENSMUSG00000024006 (Mm), ENSRNOG00000000519 (Rn)
Entrez Gene	11329 (Hs), 106504 (Mm), 361813 (Rn)
Human Protein Atlas	ENSG00000112079 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:11329 (Hs), mmu:106504 (Mm), rno:361813 (Rn)
OMIM	606964 (Hs)
Pharos	Q15208 (Hs)
RefSeq Nucleotide	NM_007271 (Hs), NM_134115 (Mm), NM_001015025 (Rn)
RefSeq Protein	NP_009202 (Hs), NP_598876 (Mm), NP_001015025 (Rn)
UniProtKB	Q15208 (Hs), Q91VJ4 (Mm)
Wikipedia	STK38 (Hs)

Enzyme Reaction
EC Number: 2.7.11.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 35 [PMID: 20684608] Hs Inhibition - - 3 ⤷ [3] Description: Measured as % inhibition using 3μM compound.
Inhibitor Comments
3μM compound 35 [PMID 20684608] inhibits STK38 activity by 72% [3].

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 2,4
Key to terms and symbols		Click column headers to sort
Target used in screen: NDR1
Ligand Sp. Type Action Value Parameter staurosporine Hs Inhibitor Inhibition 7.3 pKd lestaurtinib Hs Inhibitor Inhibition 6.7 pKd KW-2449 Hs Inhibitor Inhibition 6.4 pKd sunitinib Hs Inhibitor Inhibition 6.4 pKd NVP-TAE684 Hs Inhibitor Inhibition 6.4 pKd dovitinib Hs Inhibitor Inhibition 6.2 pKd SU-14813 Hs Inhibitor Inhibition 6.2 pKd SB203580 Hs Inhibitor Inhibition <5.5 pKd ruboxistaurin Hs Inhibitor Inhibition <5.5 pKd erlotinib Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: ...1
Key to terms and symbols		Click column headers to sort
Target used in screen: nd/STK38(NDR1)
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM staurosporine Hs Inhibitor Inhibition 10.0 K-252a Hs Inhibitor Inhibition 14.3 SB 218078 Hs Inhibitor Inhibition 46.2 PDK1/Akt/Flt dual pathway inhibitor Hs Inhibitor Inhibition 46.6 PKR inhibitor Hs Inhibitor Inhibition 51.0 Syk inhibitor Hs Inhibitor Inhibition 53.1 JAK3 inhibitor VI Hs Inhibitor Inhibition 60.0 Syk inhibitor II Hs Inhibitor Inhibition 78.7 VEGF receptor 2 kinase inhibitor II Hs Inhibitor Inhibition 80.1 midostaurin Hs Inhibitor Inhibition 83.8
Displaying the top 10 most potent ligands  View all ligands in screen »