serine/threonine kinase 32A | YANK family | IUPHAR/BPS Guide to PHARMACOLOGY

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serine/threonine kinase 32A

Target not currently curated in GtoImmuPdb

Target id: 1537

Nomenclature: serine/threonine kinase 32A

Abbreviated Name: YANK1

Family: YANK family

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 396 5q32 STK32A serine/threonine kinase 32A
Mouse - 398 18 Stk32a serine/threonine kinase 32A
Rat - 397 18p11 Stk32a serine/threonine kinase 32A
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of human serine/threonine-protein kinase 32A (YANK1).
PDB Id:  4FR4
Resolution:  2.29Å
Species:  Human
References: 
Enzyme Reaction
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: YANK1
Ligand Sp. Type Action Value Parameter
NVP-TAE684 Hs Inhibitor Inhibition 7.9 pKd
staurosporine Hs Inhibitor Inhibition 7.9 pKd
linifanib Hs Inhibitor Inhibition 6.2 pKd
PP-242 Hs Inhibitor Inhibition 6.2 pKd
SB203580 Hs Inhibitor Inhibition 5.9 pKd
bosutinib Hs Inhibitor Inhibition 5.7 pKd
lestaurtinib Hs Inhibitor Inhibition 5.7 pKd
tamatinib Hs Inhibitor Inhibition 5.6 pKd
midostaurin Hs Inhibitor Inhibition 5.6 pKd
PD-173955 Hs Inhibitor Inhibition 5.6 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

YANK family: serine/threonine kinase 32A. Last modified on 18/08/2014. Accessed on 15/08/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1537.