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Endoplasmic reticulum aminopeptidase 2

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Target not currently curated in GtoImmuPdb

Target id: 1567

Nomenclature: Endoplasmic reticulum aminopeptidase 2

Family: M1: Aminopeptidase N

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 960 5q15 ERAP2 endoplasmic reticulum aminopeptidase 2
Previous and Unofficial Names Click here for help
L-RAP | Leukocyte-derived arginine aminopeptidase
Database Links Click here for help
Specialist databases
MEROPS M01.024 (Hs)
Other databases
Alphafold
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.11.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 2g [PMID: 27390066] Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 6.8 pKi 2
pKi 6.8 (Ki 1.5x10-7 M) [2]
compound 3v [PMID: 27390066] Small molecule or natural product Primary target of this compound Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 6.2 pKi 2
pKi 6.2 (Ki 6.2x10-7 M) [2]
compound 17 [PMID: 23916253] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 5.1 pIC50 1
pIC50 5.1 (IC50 8.9x10-6 M) [1]
Immuno Process Associations
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 2 GO processes
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I TAS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0002250 adaptive immune response IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0002250 adaptive immune response IEA

References

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1. Papakyriakou A, Zervoudi E, Theodorakis EA, Saveanu L, Stratikos E, Vourloumis D. (2013) Novel selective inhibitors of aminopeptidases that generate antigenic peptides. Bioorg Med Chem Lett, 23 (17): 4832-6. [PMID:23916253]

2. Węglarz-Tomczak E, Vassiliou S, Mucha A. (2016) Discovery of potent and selective inhibitors of human aminopeptidases ERAP1 and ERAP2 by screening libraries of phosphorus-containing amino acid and dipeptide analogues. Bioorg Med Chem Lett, 26 (16): 4122-6. [PMID:27390066]

How to cite this page

M1: Aminopeptidase N: Endoplasmic reticulum aminopeptidase 2. Last modified on 20/10/2017. Accessed on 27/11/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1567.