Leucine aminopeptidase 3 | M17: Leucyl aminopeptidase | IUPHAR/BPS Guide to PHARMACOLOGY

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Leucine aminopeptidase 3

Target not currently curated in GtoImmuPdb

Target id: 1569

Nomenclature: Leucine aminopeptidase 3

Family: M17: Leucyl aminopeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 519 4p15.33 LAP3 leucine aminopeptidase 3
Mouse - 519 5 B3 Lap3 leucine aminopeptidase 3
Rat - 519 14q21 Lap3 leucine aminopeptidase 3
Previous and Unofficial Names
LAP | LAPEP | peptidase S | cytosol aminopeptidase | LAP-3 | leucine aminopeptidase 3 | proline aminopeptidase | prolyl aminopeptidase | Pep7 | PEPS
Database Links
Specialist databases
MEROPS M17.001 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
bestatin Bt Inhibition 9.2 pKi 1-2
pKi 9.2 (Ki 6x10-10 M) [1-2]


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1. Grembecka J, Mucha A, Cierpicki T, Kafarski P. (2003) The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity. J. Med. Chem., 46 (13): 2641-55. [PMID:12801228]

2. Taylor A, Peltier CZ, Torre FJ, Hakamian N. (1993) Inhibition of bovine lens leucine aminopeptidase by bestatin: number of binding sites and slow binding of this inhibitor. Biochemistry, 32 (3): 784-90. [PMID:8422382]

How to cite this page

M17: Leucyl aminopeptidase: Leucine aminopeptidase 3. Last modified on 22/07/2015. Accessed on 25/05/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1569.