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Carboxypeptidase B1 (tissue)

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Target not currently curated in GtoImmuPdb

Target id: 1593

Nomenclature: Carboxypeptidase B1 (tissue)

Family: M14: Carboxypeptidase A

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 417 3q24 CPB1 carboxypeptidase B1
Mouse - 415 3 A2 Cpb1 carboxypeptidase B1 (tissue)
Rat - 415 2q24 Cpb1 carboxypeptidase B1
Previous and Unofficial Names Click here for help
protaminase | tissue carboxypeptidase B | Cpb | pancreatic carboxypeptidase B1 | carboxypeptidase B1 (tissue)
Database Links Click here for help
Specialist databases
MEROPS M14.003 (Hs)
Other databases
Alphafold P15086 (Hs), P19223 (Rn)
BRENDA 3.4.17.2
CATH/Gene3D 3.30.70.340
ChEMBL Target CHEMBL2552 (Hs)
Ensembl Gene ENSG00000153002 (Hs), ENSMUSG00000011463 (Mm), ENSRNOG00000030904 (Rn)
Entrez Gene 1360 (Hs), 76703 (Mm), 24271 (Rn)
Human Protein Atlas ENSG00000153002 (Hs)
KEGG Enzyme 3.4.17.2
KEGG Gene hsa:1360 (Hs), mmu:76703 (Mm), rno:24271 (Rn)
OMIM 114852 (Hs)
Pharos P15086 (Hs)
RefSeq Nucleotide NM_001871 (Hs), NM_012533 (Rn)
RefSeq Protein NP_001862 (Hs), NP_036665 (Rn)
UniProtKB P15086 (Hs), P19223 (Rn)
Wikipedia CPB1 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.17.2

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 4 [PMID: 19954973] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.6 pKi 2
⤷ pKi 7.6 (Ki 2.7x10-8 M) [2]
compound 3 [PMID: 14640538] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.1 pIC50 1
⤷ pIC50 8.1 (IC50 8.2x10-9 M) [1]

References

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1. Barrow JC, Nantermet PG, Stauffer SR, Ngo PL, Steinbeiser MA, Mao SS, Carroll SS, Bailey C, Colussi D, Bosserman M et al.. (2003) Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics. J Med Chem, 46 (25): 5294-7. [PMID:14640538]

2. Owen DR, Bull DJ, Bunnage ME, Glossop MS, Maguire RJ, Strang RS. (2010) Oxygenated analogues of UK-396082 as inhibitors of activated thrombin activatable fibrinolysis inhibitor. Bioorg Med Chem Lett, 20 (1): 92-6. [PMID:19954973]

How to cite this page

M14: Carboxypeptidase A: Carboxypeptidase B1 (tissue). Last modified on 29/07/2015. Accessed on 04/12/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1593.