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Carboxypeptidase M

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1596

Nomenclature: Carboxypeptidase M

Family: M14: Carboxypeptidase A

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 443 12q15 CPM carboxypeptidase M
Mouse - 443 10 D2 Cpm carboxypeptidase M
Rat - 443 7q22 Cpm carboxypeptidase M
Previous and Unofficial Names Click here for help
renal carboxypeptidase | urinary carboxypeptidase B
Database Links Click here for help
Specialist databases
MEROPS M14.006 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 3 [PMID: 14640538] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.9 pIC50 1
pIC50 7.9 (IC50 1.3x10-8 M) [1]
Immunopharmacology Comments
Possible role in immune system discussed in [2].


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1. Barrow JC, Nantermet PG, Stauffer SR, Ngo PL, Steinbeiser MA, Mao SS, Carroll SS, Bailey C, Colussi D, Bosserman M et al.. (2003) Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics. J Med Chem, 46 (25): 5294-7. [PMID:14640538]

2. Deiteren K, Hendriks D, Scharpé S, Lambeir AM. (2009) Carboxypeptidase M: Multiple alliances and unknown partners. Clin Chim Acta, 399 (1-2): 24-39. [PMID:18957287]

How to cite this page

M14: Carboxypeptidase A: Carboxypeptidase M. Last modified on 25/07/2016. Accessed on 08/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY,