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Carboxypeptidase M

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1596

Nomenclature: Carboxypeptidase M

Family: M14: Carboxypeptidase A

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 443 12q15 CPM carboxypeptidase M
Mouse - 443 10 D2 Cpm carboxypeptidase M
Rat - 443 7q22 Cpm carboxypeptidase M
Previous and Unofficial Names Click here for help
renal carboxypeptidase | urinary carboxypeptidase B
Database Links Click here for help
Specialist databases
MEROPS M14.006 (Hs)
Other databases
Alphafold P14384 (Hs), Q80V42 (Mm), D4A9Q5 (Rn)
BRENDA 3.4.17.12
ChEMBL Target CHEMBL3038 (Hs)
Ensembl Gene ENSG00000135678 (Hs), ENSMUSG00000020183 (Mm), ENSRNOG00000066159 (Rn)
Entrez Gene 1368 (Hs), 70574 (Mm), 314855 (Rn)
Human Protein Atlas ENSG00000135678 (Hs)
KEGG Enzyme 3.4.17.12
KEGG Gene hsa:1368 (Hs), mmu:70574 (Mm), rno:314855 (Rn)
OMIM 114860 (Hs)
Pharos P14384 (Hs)
RefSeq Nucleotide NM_001005502 (Hs), NM_001874 (Hs), NM_198320 (Hs), NM_027468 (Mm), NM_001108098 (Rn)
RefSeq Protein NP_938079 (Hs), NP_001005502 (Hs), NP_001865 (Hs), NP_081744 (Mm), NP_001101568 (Rn)
UniProtKB P14384 (Hs), Q80V42 (Mm), D4A9Q5 (Rn)
Wikipedia CPM (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.17.12

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 3 [PMID: 14640538] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.9 pIC50 1
⤷ pIC50 7.9 (IC50 1.3x10-8 M) [1]
Immunopharmacology Comments
Possible role in immune system discussed in [2].

References

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1. Barrow JC, Nantermet PG, Stauffer SR, Ngo PL, Steinbeiser MA, Mao SS, Carroll SS, Bailey C, Colussi D, Bosserman M et al.. (2003) Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics. J Med Chem, 46 (25): 5294-7. [PMID:14640538]

2. Deiteren K, Hendriks D, Scharpé S, Lambeir AM. (2009) Carboxypeptidase M: Multiple alliances and unknown partners. Clin Chim Acta, 399 (1-2): 24-39. [PMID:18957287]

How to cite this page

M14: Carboxypeptidase A: Carboxypeptidase M. Last modified on 25/07/2016. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1596.