Carboxypeptidase M | M14: Carboxypeptidase A | IUPHAR/BPS Guide to PHARMACOLOGY

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Carboxypeptidase M

target has curated data in GtoImmuPdb

Target id: 1596

Nomenclature: Carboxypeptidase M

Family: M14: Carboxypeptidase A

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 443 12q15 CPM carboxypeptidase M
Mouse - 443 10 D2 Cpm carboxypeptidase M
Rat - 443 7q22 Cpm carboxypeptidase M
Previous and Unofficial Names
renal carboxypeptidase | urinary carboxypeptidase B
Database Links
Specialist databases
MEROPS M14.006 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 3 [PMID: 14640538] Hs Inhibition 7.9 pIC50 1
pIC50 7.9 (IC50 1.3x10-8 M) [1]
Immunopharmacology Comments
Possible role in immune system discussed in [2].


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1. Barrow JC, Nantermet PG, Stauffer SR, Ngo PL, Steinbeiser MA, Mao SS, Carroll SS, Bailey C, Colussi D, Bosserman M et al.. (2003) Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics. J. Med. Chem., 46 (25): 5294-7. [PMID:14640538]

2. Deiteren K, Hendriks D, ScharpĂ© S, Lambeir AM. (2009) Carboxypeptidase M: Multiple alliances and unknown partners. Clin. Chim. Acta, 399 (1-2): 24-39. [PMID:18957287]

How to cite this page

M14: Carboxypeptidase A: Carboxypeptidase M. Last modified on 25/07/2016. Accessed on 12/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY,