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Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 267 | 11q22.2 | MMP7 | matrix metallopeptidase 7 | |
Mouse | - | 264 | 9 2.46 cM | Mmp7 | matrix metallopeptidase 7 | |
Rat | - | 267 | 8q11 | Mmp7 | matrix metallopeptidase 7 |
Previous and Unofficial Names |
matrin | PUMP-1 protease | uterine metalloproteinase | MPMM | MAT | MPSL1 | matrix metallopeptidase 7 (matrilysin, uterine) |
Database Links | |
Specialist databases | |
MEROPS | M10.008 (Hs) |
Other databases | |
Alphafold | P09237 (Hs), Q10738 (Mm), P50280 (Rn) |
BRENDA | 3.4.24.23 |
CATH/Gene3D | 3.40.390.10 |
ChEMBL Target | CHEMBL4073 (Hs) |
DrugBank Target | P09237 (Hs) |
Ensembl Gene | ENSG00000137673 (Hs), ENSMUSG00000018623 (Mm), ENSRNOG00000010507 (Rn) |
Entrez Gene | 4316 (Hs), 17393 (Mm), 25335 (Rn) |
Human Protein Atlas | ENSG00000137673 (Hs) |
KEGG Enzyme | 3.4.24.23 |
KEGG Gene | hsa:4316 (Hs), mmu:17393 (Mm), rno:25335 (Rn) |
OMIM | 178990 (Hs) |
Pharos | P09237 (Hs) |
RefSeq Nucleotide | NM_002423 (Hs), NM_010810 (Mm), NM_012864 (Rn) |
RefSeq Protein | NP_002414 (Hs), NP_034940 (Mm), NP_036996 (Rn) |
UniProtKB | P09237 (Hs), Q10738 (Mm), P50280 (Rn) |
Wikipedia | MMP7 (Hs) |
Enzyme Reaction | ||||
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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SL422 is a broad-spectrum inhibitor of MMP enzymes [5]. |
1. Chen JJ, Zhang Y, Hammond S, Dewdney N, Ho T, Lin X, Browner MF, Castelhano AL. (1996) Design, synthesis, activity, and structure of a novel class of matrix metalloproteinase inhibitors containing a heterocyclic P2′-P3′ amide bond isostere. Bioorg Med Chem Lett, 6: 1601-1606.
2. García RA, Pantazatos DP, Gessner CR, Go KV, Woods Jr VL, Villarreal FJ. (2005) Molecular interactions between matrilysin and the matrix metalloproteinase inhibitor doxycycline investigated by deuterium exchange mass spectrometry. Mol Pharmacol, 67 (4): 1128-36. [PMID:15665254]
3. Rasmussen HS, McCann PP. (1997) Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat. Pharmacol Ther, 75 (1): 69-75. [PMID:9364582]
4. Takeuchi T, Hayashi M, Tamita T, Nomura Y, Kojima N, Mitani A, Takeda T, Hitaka K, Kato Y, Kamitani M et al.. (2022) Discovery of Aryloxyphenyl-Heptapeptide Hybrids as Potent and Selective Matrix Metalloproteinase-2 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis. J Med Chem, 65 (12): 8493-8510. [PMID:35687819]
5. Xue CB, Voss ME, Nelson DJ, Duan JJ, Cherney RJ, Jacobson IC, He X, Roderick J, Chen L, Corbett RL et al.. (2001) Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. J Med Chem, 44 (16): 2636-60. [PMID:11472217]
M10: Matrix metallopeptidase: MMP7. Last modified on 12/07/2022. Accessed on 07/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1631.