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MMP10

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Target not currently curated in GtoImmuPdb

Target id: 1634

Nomenclature: MMP10

Family: M10: Matrix metallopeptidase

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 476 11q22.2 MMP10 matrix metallopeptidase 10
Mouse - 476 9 A1 Mmp10 matrix metallopeptidase 10
Rat - 476 8q11 Mmp10 matrix metallopeptidase 10
Previous and Unofficial Names Click here for help
transin-2 | SL-2 | transformation-associated protein 34A | STMY2 | matrix metallopeptidase 10 (stromelysin 2)
Database Links Click here for help
Specialist databases
MEROPS M10.006 (Hs)
Other databases
Alphafold P09238 (Hs), O55123 (Mm), P07152 (Rn)
BRENDA 3.4.24.22
CATH/Gene3D 2.110.10.10, 3.40.390.10
ChEMBL Target CHEMBL4270 (Hs)
DrugBank Target P09238 (Hs)
Ensembl Gene ENSG00000166670 (Hs), ENSMUSG00000047562 (Mm), ENSRNOG00000032832 (Rn)
Entrez Gene 4319 (Hs), 17384 (Mm), 117061 (Rn)
Human Protein Atlas ENSG00000166670 (Hs)
KEGG Enzyme 3.4.24.22
KEGG Gene hsa:4319 (Hs), mmu:17384 (Mm), rno:117061 (Rn)
OMIM 185260 (Hs)
Pharos P09238 (Hs)
RefSeq Nucleotide NM_002425 (Hs), NM_019471 (Mm), NM_133514 (Rn)
RefSeq Protein NP_002416 (Hs), NP_062344 (Mm), NP_598198 (Rn)
UniProtKB P09238 (Hs), O55123 (Mm), P07152 (Rn)
Wikipedia MMP10 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.24.22

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
CM-352 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 7.8 pIC50 2
⤷ pIC50 7.8 (IC50 1.5x10-8 M) [2]
marimastat Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.2 pIC50 1
⤷ pIC50 7.2 (IC50 6.9x10-8 M) [1]
MMP13 tracer [18F]5j Small molecule or natural product Click here for species-specific activity table Ligand is labelled Ligand is radioactive Hs Inhibition 5.5 pIC50 1
⤷ pIC50 5.5 (IC50 3.1x10-6 M) [1]

References

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1. Buchler A, Ismailani US, MacMullin N, Abdirahman F, Adi M, Bi C, Jany C, Keillor JW, Rotstein BH. (2023) Quinazoline-2-Carboxamides as Selective PET Radiotracers for Matrix Metalloproteinase-13 Imaging in Atherosclerosis. J Med Chem, 66 (10): 6682-6696. [PMID:37158732]

2. Orbe J, Rodríguez JA, Sánchez-Arias JA, Salicio A, Belzunce M, Ugarte A, Chang HC, Rabal O, Oyarzabal J, Páramo JA. (2015) Discovery and safety profiling of a potent preclinical candidate, (4-[4-[[(3R)-3-(hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]-N-methylbenzamide) (CM-352), for the prevention and treatment of hemorrhage. J Med Chem, 58 (7): 2941-57. [PMID:25686022]

How to cite this page

M10: Matrix metallopeptidase: MMP10. Last modified on 10/05/2023. Accessed on 04/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1634.