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Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 669 | 16q21 | MMP15 | matrix metallopeptidase 15 | |
Mouse | 1 | 657 | 8 47.12 cM | Mmp15 | matrix metallopeptidase 15 | |
Rat | 1 | 657 | 19p13 | Mmp15 | matrix metallopeptidase 15 |
Previous and Unofficial Names |
Membrane type 2-MMP | MTMMP2 | SMCP-2 | matrix metallopeptidase 15 (membrane-inserted) |
Database Links | |
Specialist databases | |
MEROPS | M10.015 (Hs) |
Other databases | |
Alphafold | P51511 (Hs), O54732 (Mm), D3ZCG5 (Rn) |
BRENDA | 3.4.24.- |
CATH/Gene3D | 2.110.10.10, 3.40.390.10 |
ChEMBL Target | CHEMBL2963 (Hs) |
DrugBank Target | P51511 (Hs) |
Ensembl Gene | ENSG00000102996 (Hs), ENSMUSG00000031790 (Mm), ENSRNOG00000012622 (Rn) |
Entrez Gene | 4324 (Hs), 17388 (Mm), 291848 (Rn) |
Human Protein Atlas | ENSG00000102996 (Hs) |
KEGG Enzyme | 3.4.24.- |
KEGG Gene | hsa:4324 (Hs), mmu:17388 (Mm), rno:291848 (Rn) |
OMIM | 602261 (Hs) |
Pharos | P51511 (Hs) |
RefSeq Nucleotide | NM_002428 (Hs), NM_008609 (Mm), NM_001106168 (Rn) |
RefSeq Protein | NP_002419 (Hs), NP_032635 (Mm), NP_001099638 (Rn) |
UniProtKB | P51511 (Hs), O54732 (Mm), D3ZCG5 (Rn) |
Wikipedia | MMP15 (Hs) |
Enzyme Reaction | ||||
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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1. Ma D, Wu W, Yang G, Li J, Li J, Ye Q. (2004) Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors. Bioorg Med Chem Lett, 14 (1): 47-50. [PMID:14684295]
2. Xue CB, Voss ME, Nelson DJ, Duan JJ, Cherney RJ, Jacobson IC, He X, Roderick J, Chen L, Corbett RL et al.. (2001) Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. J Med Chem, 44 (16): 2636-60. [PMID:11472217]
M10: Matrix metallopeptidase: MMP15. Last modified on 16/03/2017. Accessed on 07/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1639.