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MMP15

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Target not currently curated in GtoImmuPdb

Target id: 1639

Nomenclature: MMP15

Family: M10: Matrix metallopeptidase

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 669 16q21 MMP15 matrix metallopeptidase 15
Mouse 1 657 8 47.12 cM Mmp15 matrix metallopeptidase 15
Rat 1 657 19p13 Mmp15 matrix metallopeptidase 15
Previous and Unofficial Names Click here for help
Membrane type 2-MMP | MTMMP2 | SMCP-2 | matrix metallopeptidase 15 (membrane-inserted)
Database Links Click here for help
Specialist databases
MEROPS M10.015 (Hs)
Other databases
Alphafold P51511 (Hs), O54732 (Mm), D3ZCG5 (Rn)
BRENDA 3.4.24.-
CATH/Gene3D 2.110.10.10, 3.40.390.10
ChEMBL Target CHEMBL2963 (Hs)
DrugBank Target P51511 (Hs)
Ensembl Gene ENSG00000102996 (Hs), ENSMUSG00000031790 (Mm), ENSRNOG00000012622 (Rn)
Entrez Gene 4324 (Hs), 17388 (Mm), 291848 (Rn)
Human Protein Atlas ENSG00000102996 (Hs)
KEGG Enzyme 3.4.24.-
KEGG Gene hsa:4324 (Hs), mmu:17388 (Mm), rno:291848 (Rn)
OMIM 602261 (Hs)
Pharos P51511 (Hs)
RefSeq Nucleotide NM_002428 (Hs), NM_008609 (Mm), NM_001106168 (Rn)
RefSeq Protein NP_002419 (Hs), NP_032635 (Mm), NP_001099638 (Rn)
UniProtKB P51511 (Hs), O54732 (Mm), D3ZCG5 (Rn)
Wikipedia MMP15 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
SL422 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.7 pKi 2
⤷ pKi 7.7 (Ki 2x10-8 M) [2]
ilomastat Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.1 pIC50 1
⤷ pIC50 8.1 (IC50 8x10-9 M) [1]

References

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1. Ma D, Wu W, Yang G, Li J, Li J, Ye Q. (2004) Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors. Bioorg Med Chem Lett, 14 (1): 47-50. [PMID:14684295]

2. Xue CB, Voss ME, Nelson DJ, Duan JJ, Cherney RJ, Jacobson IC, He X, Roderick J, Chen L, Corbett RL et al.. (2001) Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. J Med Chem, 44 (16): 2636-60. [PMID:11472217]

How to cite this page

M10: Matrix metallopeptidase: MMP15. Last modified on 16/03/2017. Accessed on 07/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1639.