Top ▲
GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.
Gene and Protein Information  |
||||||
| class A G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 351 | 6q23.2 | TAAR2 | trace amine associated receptor 2 | 6 |
| Mouse | 7 | 339 | 10 A4 | Taar2 | trace amine-associated receptor 2 | |
| Rat | 7 | 339 | 1p12 | Taar2 | trace amine associated receptor 2 | |
| Previous and Unofficial Names |
| GPR58 | G protein-coupled receptor 58 | trace amine receptor 2 | trace amine associated receptor 2 (gene/pseudogene) |
| Database Links |
|
| Specialist databases | |
| GPCRdb | taar2_human (Hs), taar2_mouse (Mm), taar2_rat (Rn) |
| Other databases | |
| Alphafold | Q9P1P5 (Hs), Q5QD17 (Mm), Q5QD25 (Rn) |
| ChEMBL Target | CHEMBL4523927 (Hs) |
| Ensembl Gene | ENSG00000146378 (Hs), ENSMUSG00000059763 (Mm), ENSRNOG00000025951 (Rn) |
| Entrez Gene | 9287 (Hs), 209512 (Mm), 294121 (Rn) |
| Human Protein Atlas | ENSG00000146378 (Hs) |
| KEGG Gene | hsa:9287 (Hs), mmu:209512 (Mm), rno:294121 (Rn) |
| OMIM | 604849 (Hs) |
| Pharos | Q9P1P5 (Hs) |
| RefSeq Nucleotide | NM_001033080 (Hs), NM_001007266 (Mm), NM_001008512 (Rn) |
| RefSeq Protein | NP_001028252 (Hs), NP_001007267 (Mm), NP_001008512 (Rn) |
| UniProtKB | Q9P1P5 (Hs), Q5QD17 (Mm), Q5QD25 (Rn) |
| Wikipedia | TAAR2 (Hs) |
| Potency order of endogenous ligands |
| β-phenylethylamine > tryptamine [2] |
| Primary Transduction Mechanisms
|
|
| Comments: TAAR2 is found to be coexpressed with Gα proteins. However, the transduction pathway of TAAR2 is yet to be determined. | |
| References: 7 |
| Tissue Distribution
|
||||||||
|
||||||||
|
||||||||
|
||||||||
|
||||||||
| Tissue Distribution Comments | ||||||||
| No TAAR2 mRNAs were detected by Northern blot analysis in the pons, thalamus, hypothalamus, hippocampus, caudate, putamen, frontal cortex, basal forebrain, midbrain and liver [6]. | ||||||||
| Expression Datasets |
|
|
| Clinically-Relevant Mutations and Pathophysiology Comments |
| A SNP nonsense mutation in the TAAR2 gene has been associated with schizophrenia [1]. |
| Biologically Significant Variants
|
||||||||||||||||
|
||||||||||||||||
|
||||||||||||||||
|
||||||||||||||||
|
||||||||||||||||
|
||||||||||||||||
|
| General Comments |
| Probable pseudogene in 10–15% of Asians due to a polymorphism (rs8192646) producing a premature stop codon at amino acid 168 [3]. |
1. Bly M. (2005) Examination of the trace amine-associated receptor 2 (TAAR2). Schizophr Res, 80 (2-3): 367-8. [PMID:15993565]
2. Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S et al.. (2001) Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci USA, 98 (16): 8966-71. [PMID:11459929]
3. Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR et al.. (2013) International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev, 65 (3): 967-86. [PMID:23686350]
4. Fleischer J, Schwarzenbacher K, Breer H. (2007) Expression of trace amine-associated receptors in the Grueneberg ganglion. Chem Senses, 32 (6): 623-31. [PMID:17556730]
5. Ito J, Ito M, Nambu H, Fujikawa T, Tanaka K, Iwaasa H, Tokita S. (2009) Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL/6J mice. Cell Tissue Res, 338 (2): 257-69. [PMID:19763624]
6. Lee DK, Lynch KR, Nguyen T, Im DS, Cheng R, Saldivia VR, Liu Y, Liu IS, Heng HH, Seeman P, George SR, O'Dowd BF, Marchese A. (2000) Cloning and characterization of additional members of the G protein-coupled receptor family. Biochim Biophys Acta, 1490 (3): 311-23. [PMID:10684976]
7. Liberles SD, Buck LB. (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature, 442: 645-650. [PMID:16878137]
8. Zucchi R, Chiellini G, Scanlan TS, Grandy DK. (2006) Trace amine-associated receptors and their ligands. Br J Pharmacol, 149 (8): 967-78. [PMID:17088868]
