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TAAR2

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Target not currently curated in GtoImmuPdb

Target id: 167

Nomenclature: TAAR2

Family: Class A Orphans

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 351 6q23.2 TAAR2 trace amine associated receptor 2 6
Mouse 7 339 10 A4 Taar2 trace amine-associated receptor 2
Rat 7 339 1p12 Taar2 trace amine associated receptor 2
Previous and Unofficial Names Click here for help
GPR58 | G protein-coupled receptor 58 | trace amine receptor 2 | trace amine associated receptor 2 (gene/pseudogene)
Database Links Click here for help
Specialist databases
GPCRdb taar2_human (Hs), taar2_mouse (Mm), taar2_rat (Rn)
Other databases
Alphafold Q9P1P5 (Hs), Q5QD17 (Mm), Q5QD25 (Rn)
ChEMBL Target CHEMBL4523927 (Hs)
Ensembl Gene ENSG00000146378 (Hs), ENSMUSG00000059763 (Mm), ENSRNOG00000025951 (Rn)
Entrez Gene 9287 (Hs), 209512 (Mm), 294121 (Rn)
Human Protein Atlas ENSG00000146378 (Hs)
KEGG Gene hsa:9287 (Hs), mmu:209512 (Mm), rno:294121 (Rn)
OMIM 604849 (Hs)
Pharos Q9P1P5 (Hs)
RefSeq Nucleotide NM_001033080 (Hs), NM_001007266 (Mm), NM_001008512 (Rn)
RefSeq Protein NP_001028252 (Hs), NP_001007267 (Mm), NP_001008512 (Rn)
UniProtKB Q9P1P5 (Hs), Q5QD17 (Mm), Q5QD25 (Rn)
Wikipedia TAAR2 (Hs)
Potency order of endogenous ligands
β-phenylethylamine > tryptamine  [2]
Primary Transduction Mechanisms Click here for help
Comments:  TAAR2 is found to be coexpressed with Gα proteins. However, the transduction pathway of TAAR2 is yet to be determined.
References:  7
Tissue Distribution Click here for help
Olfactory epithelium
Species:  Mouse
Technique:  RT-PCR and in situ hybridisation.
References:  7
Mucosal layer of gastrointestinal tract, predominantly in duodenum.
Species:  Mouse
Technique:  RT-PCR
References:  5
Cells of Grueneberg ganglion
Species:  Mouse
Technique:  in situ hybridisation
References:  4
Heart
Species:  Rat
Technique: 
References:  8
Tissue Distribution Comments
No TAAR2 mRNAs were detected by Northern blot analysis in the pons, thalamus, hypothalamus, hippocampus, caudate, putamen, frontal cortex, basal forebrain, midbrain and liver [6].
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Clinically-Relevant Mutations and Pathophysiology Comments
A SNP nonsense mutation in the TAAR2 gene has been associated with schizophrenia [1].
Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  S130F
SNP accession:  rs61731216
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  F131L
Global MAF (%):  17
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 49|11|11|3
Minor allele count:  A=0.167/365
SNP accession:  rs61745666
Validation:  1000 Genomes, Frequency, Cluster
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  R43Q
Global MAF (%):  3
Subpopulation MAF (%):  AFR|AMR: 14|1
Minor allele count:  T=0.034/75
SNP accession:  rs73775147
Validation:  1000 Genomes, Frequency, Cluster
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  S85F
Global MAF (%):  3
Subpopulation MAF (%):  AFR|AMR: 14|1
Minor allele count:  A=0.034/75
SNP accession:  rs61731216
Validation:  1000 Genomes, Frequency, Cluster
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  W168X
Comment on frequency:  Found in 10-15% of Asian population
SNP accession:  rs8192646
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  S85F
Comment on frequency:  Low frequency (<10% in tested population)
SNP accession:  rs61731216
General Comments
Probable pseudogene in 10–15% of Asians due to a polymorphism (rs8192646) producing a premature stop codon at amino acid 168 [3].

References

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1. Bly M. (2005) Examination of the trace amine-associated receptor 2 (TAAR2). Schizophr Res, 80 (2-3): 367-8. [PMID:15993565]

2. Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S et al.. (2001) Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci USA, 98 (16): 8966-71. [PMID:11459929]

3. Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR et al.. (2013) International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev, 65 (3): 967-86. [PMID:23686350]

4. Fleischer J, Schwarzenbacher K, Breer H. (2007) Expression of trace amine-associated receptors in the Grueneberg ganglion. Chem Senses, 32 (6): 623-31. [PMID:17556730]

5. Ito J, Ito M, Nambu H, Fujikawa T, Tanaka K, Iwaasa H, Tokita S. (2009) Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL/6J mice. Cell Tissue Res, 338 (2): 257-69. [PMID:19763624]

6. Lee DK, Lynch KR, Nguyen T, Im DS, Cheng R, Saldivia VR, Liu Y, Liu IS, Heng HH, Seeman P, George SR, O'Dowd BF, Marchese A. (2000) Cloning and characterization of additional members of the G protein-coupled receptor family. Biochim Biophys Acta, 1490 (3): 311-23. [PMID:10684976]

7. Liberles SD, Buck LB. (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature, 442: 645-650. [PMID:16878137]

8. Zucchi R, Chiellini G, Scanlan TS, Grandy DK. (2006) Trace amine-associated receptors and their ligands. Br J Pharmacol, 149 (8): 967-78. [PMID:17088868]

Contributors

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