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EPH receptor B6

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Target not currently curated in GtoImmuPdb

Target id: 1834

Nomenclature: EPH receptor B6

Abbreviated Name: EphB6

Family: Type XIII RTKs: Ephrin receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 1021 7q34 EPHB6 EPH receptor B6
Mouse 1 1014 6 B2.1 Ephb6 Eph receptor B6
Rat 1 1013 4q23 Ephb6 Eph receptor B6
Previous and Unofficial Names Click here for help
ephrin type-B receptor 6 | tyrosine-protein kinase-defective receptor EPH-6 | MEP | Cekl
Database Links Click here for help
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 2.7.10.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 20 [PMID: 23489211] Small molecule or natural product Click here for species-specific activity table Mm Inhibition 5.2 pIC50 2
pIC50 5.2 (IC50 5.8x10-6 M) [2]
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1,3

Key to terms and symbols Click column headers to sort
Target used in screen: EPHB6
Ligand Sp. Type Action Value Parameter
dasatinib Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 10.4 pKd
foretinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.9 pKd
PD-173955 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.7 pKd
Ki-20227 Small molecule or natural product Hs Inhibitor Inhibition 8.3 pKd
crizotinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 8.2 pKd
tozasertib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.6 pKd
linifanib Small molecule or natural product Hs Inhibitor Inhibition 7.5 pKd
CHIR-265 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.4 pKd
barasertib-hQPA Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.3 pKd
vandetanib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 7.1 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »
Immuno Process Associations
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 2 GO processes
GO:0001806 type IV hypersensitivity IMP
GO:0002456 T cell mediated immunity IMP
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 2 GO processes
GO:0050798 activated T cell proliferation IMP
GO:2000525 positive regulation of T cell costimulation IGI
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:2000525 positive regulation of T cell costimulation IGI
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0050663 cytokine secretion IMP
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:2000525 positive regulation of T cell costimulation IGI
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0001806 type IV hypersensitivity IMP
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 4 GO processes
GO:0001806 type IV hypersensitivity IMP
GO:0002456 T cell mediated immunity IMP
GO:0050798 activated T cell proliferation IMP
GO:2000525 positive regulation of T cell costimulation IGI

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Incerti M, Tognolini M, Russo S, Pala D, Giorgio C, Hassan-Mohamed I, Noberini R, Pasquale EB, Vicini P, Piersanti S et al.. (2013) Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J. Med. Chem., 56 (7): 2936-47. [PMID:23489211]

3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

Type XIII RTKs: Ephrin receptor family: EPH receptor B6. Last modified on 09/02/2015. Accessed on 24/11/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1834.