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EPH receptor B6

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Target not currently curated in GtoImmuPdb

Target id: 1834

Nomenclature: EPH receptor B6

Abbreviated Name: EphB6

Family: Type XIII RTKs: Ephrin receptor family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 1021 7q34 EPHB6 EPH receptor B6
Mouse 1 1014 6 B2.1 Ephb6 Eph receptor B6
Rat 1 1013 4q23 Ephb6 Eph receptor B6
Previous and Unofficial Names Click here for help
ephrin type-B receptor 6 | tyrosine-protein kinase-defective receptor EPH-6 | MEP | Cekl
Database Links Click here for help
BRENDA 2.7.10.1
CATH/Gene3D 2.60.120.260, 2.60.40.10
ChEMBL Target CHEMBL5836 (Hs)
Ensembl Gene ENSG00000106123 (Hs), ENSMUSG00000029869 (Mm), ENSRNOG00000014367 (Rn)
Entrez Gene 2051 (Hs), 13848 (Mm), 312275 (Rn)
Human Protein Atlas ENSG00000106123 (Hs)
KEGG Enzyme 2.7.10.1
KEGG Gene hsa:2051 (Hs), mmu:13848 (Mm), rno:312275 (Rn)
OMIM 602757 (Hs)
Pharos O15197 (Hs)
RefSeq Nucleotide NM_004445 (Hs), NM_001146351 (Mm), NM_001107857 (Rn)
RefSeq Protein NP_004436 (Hs), NP_031706 (Mm), NP_001139823 (Mm), NP_001101327 (Rn)
UniProtKB O15197 (Hs), O08644 (Mm), P0C0K7 (Rn)
Wikipedia EPHB6 (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.10.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 20 [PMID: 23489211] Small molecule or natural product Click here for species-specific activity table Mm Inhibition 5.2 pIC50 2
⤷ pIC50 5.2 (IC50 5.8x10-6 M) [2]
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1,3
Key to terms and symbols Click column headers to sort
Target used in screen: EPHB6
Ligand Sp. Type Action Value Parameter
dasatinib Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 10.4 pKd
foretinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.9 pKd
PD-173955 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.7 pKd
Ki-20227 Small molecule or natural product Hs Inhibitor Inhibition 8.3 pKd
crizotinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 8.2 pKd
tozasertib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.6 pKd
linifanib Small molecule or natural product Hs Inhibitor Inhibition 7.5 pKd
CHIR-265 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.4 pKd
barasertib-hQPA Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.3 pKd
vandetanib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 7.1 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »
Immuno Process Associations
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 2 GO processes
GO:0001806 type IV hypersensitivity IMP
GO:0002456 T cell mediated immunity IMP
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 2 GO processes
GO:0050798 activated T cell proliferation IMP
GO:2000525 positive regulation of T cell costimulation IGI
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:2000525 positive regulation of T cell costimulation IGI
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0050663 cytokine secretion IMP
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:2000525 positive regulation of T cell costimulation IGI
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0001806 type IV hypersensitivity IMP
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 4 GO processes
GO:0001806 type IV hypersensitivity IMP
GO:0002456 T cell mediated immunity IMP
GO:0050798 activated T cell proliferation IMP
GO:2000525 positive regulation of T cell costimulation IGI

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Incerti M, Tognolini M, Russo S, Pala D, Giorgio C, Hassan-Mohamed I, Noberini R, Pasquale EB, Vicini P, Piersanti S et al.. (2013) Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J. Med. Chem., 56 (7): 2936-47. [PMID:23489211]

3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

Type XIII RTKs: Ephrin receptor family: EPH receptor B6. Last modified on 09/02/2015. Accessed on 24/11/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1834.