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Target not currently curated in GtoImmuPdb
Target id: 1834
Nomenclature: EPH receptor B6
Abbreviated Name: EphB6
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 1021 | 7q34 | EPHB6 | EPH receptor B6 | |
| Mouse | 1 | 1014 | 6 B2.1 | Ephb6 | Eph receptor B6 | |
| Rat | 1 | 1013 | 4q23 | Ephb6 | Eph receptor B6 | |
| Previous and Unofficial Names |
| ephrin type-B receptor 6 | tyrosine-protein kinase-defective receptor EPH-6 | MEP | Cekl |
| Database Links |
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| Alphafold | O15197 (Hs), O08644 (Mm), P0C0K7 (Rn) |
| BRENDA | 2.7.10.1 |
| CATH/Gene3D | 2.60.120.260, 2.60.40.10 |
| ChEMBL Target | CHEMBL5836 (Hs), CHEMBL4739668 (Mm) |
| Ensembl Gene | ENSG00000106123 (Hs), ENSMUSG00000029869 (Mm), ENSRNOG00000014367 (Rn) |
| Entrez Gene | 2051 (Hs), 13848 (Mm), 312275 (Rn) |
| Human Protein Atlas | ENSG00000106123 (Hs) |
| KEGG Enzyme | 2.7.10.1 |
| KEGG Gene | hsa:2051 (Hs), mmu:13848 (Mm), rno:312275 (Rn) |
| OMIM | 602757 (Hs) |
| Pharos | O15197 (Hs) |
| RefSeq Nucleotide | NM_004445 (Hs), NM_001146351 (Mm), NM_001107857 (Rn) |
| RefSeq Protein | NP_004436 (Hs), NP_031706 (Mm), NP_001139823 (Mm), NP_001101327 (Rn) |
| UniProtKB | O15197 (Hs), O08644 (Mm), P0C0K7 (Rn) |
| Wikipedia | EPHB6 (Hs) |
| Enzyme Reaction |
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Download all structure-activity data for this target as a CSV file 
| Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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| DiscoveRx KINOMEscan® screen |
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A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1,3 |
 
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| Target used in screen: EPHB6 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Displaying the top 10 most potent ligands View all ligands in screen » | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]
2. Incerti M, Tognolini M, Russo S, Pala D, Giorgio C, Hassan-Mohamed I, Noberini R, Pasquale EB, Vicini P, Piersanti S et al.. (2013) Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem, 56 (7): 2936-47. [PMID:23489211]
3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]
Type XIII RTKs: Ephrin receptor family: EPH receptor B6. Last modified on 09/02/2015. Accessed on 02/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1834.
