BUB1 mitotic checkpoint serine/threonine kinase B | Bub family | IUPHAR/BPS Guide to PHARMACOLOGY

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BUB1 mitotic checkpoint serine/threonine kinase B

Target not currently curated in GtoImmuPdb

Target id: 1950

Nomenclature: BUB1 mitotic checkpoint serine/threonine kinase B

Abbreviated Name: BubR1

Family: Bub family

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1050 15q15 BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
Mouse - 1052 2 E5 Bub1b BUB1B
Rat - 1052 3q35 Bub1b BUB1 mitotic checkpoint serine/threonine kinase B
Previous and Unofficial Names
Bub1A | BUBR1 | SSK1 | MAD3/BUB1-related protein kinase | Mitotic checkpoint kinase MAD3L | BUB1B, mitotic checkpoint serine/threonine kinase | BUB1B
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of the N-terminal domain of BUBR1
PDB Id:  2WVI
Resolution:  1.8Å
Species:  Human
References:  1
Enzyme Reaction
EC Number: 2.7.11.1
Clinically-Relevant Mutations and Pathophysiology
Disease:  Mosaic variegated aneuploidy syndrome 1; MVA1
Synonyms: Mosaic variegated aneuploidy syndrome [Orphanet: ORPHA1052]
OMIM: 257300
Orphanet: ORPHA1052
Disease:  Premature chromatid separation trait
OMIM: 176430

References

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1. D'Arcy S, Davies OR, Blundell TL, Bolanos-Garcia VM. (2010) Defining the molecular basis of BubR1 kinetochore interactions and APC/C-CDC20 inhibition. J. Biol. Chem., 285 (19): 14764-76. [PMID:20220147]

How to cite this page

Bub family: BUB1 mitotic checkpoint serine/threonine kinase B. Last modified on 18/08/2014. Accessed on 28/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1950.