BUB1 mitotic checkpoint serine/threonine kinase B | Bub family | IUPHAR/BPS Guide to PHARMACOLOGY

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BUB1 mitotic checkpoint serine/threonine kinase B

Target not currently curated in GtoImmuPdb

Target id: 1950

Nomenclature: BUB1 mitotic checkpoint serine/threonine kinase B

Abbreviated Name: BubR1

Family: Bub family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1050 15q15 BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
Mouse - 1052 2 E5 Bub1b BUB1B, mitotic checkpoint serine/threonine kinase
Rat - 1052 3q35 Bub1b BUB1 mitotic checkpoint serine/threonine kinase B
Previous and Unofficial Names
Bub1A | BUBR1 | SSK1 | MAD3/BUB1-related protein kinase | Mitotic checkpoint kinase MAD3L | BUB1B, mitotic checkpoint serine/threonine kinase | BUB1B
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of the N-terminal domain of BUBR1
Resolution:  1.8Å
Species:  Human
References:  1
Enzyme Reaction
EC Number:
Clinically-Relevant Mutations and Pathophysiology
Disease:  Mosaic variegated aneuploidy syndrome 1; MVA1
Synonyms: Mosaic variegated aneuploidy syndrome [Orphanet: ORPHA1052]
OMIM: 257300
Orphanet: ORPHA1052
Disease:  Premature chromatid separation trait
OMIM: 176430


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1. D'Arcy S, Davies OR, Blundell TL, Bolanos-Garcia VM. (2010) Defining the molecular basis of BubR1 kinetochore interactions and APC/C-CDC20 inhibition. J. Biol. Chem., 285 (19): 14764-76. [PMID:20220147]

How to cite this page

Bub family: BUB1 mitotic checkpoint serine/threonine kinase B. Last modified on 18/08/2014. Accessed on 27/01/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1950.