Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	523	12q23.1	CDK17	cyclin dependent kinase 17
Mouse	-	523	10 C2	Cdk17	cyclin dependent kinase 17
Rat	-	523	7q13	Cdk17	cyclin-dependent kinase 17

Previous and Unofficial Names

PCTAIRE protein kinase 2 | PCTAIRE2 | cyclin-dependent kinase 17

Database Links
Alphafold	Q00537 (Hs), Q8K0D0 (Mm), O35831 (Rn)
BRENDA	2.7.11.22
ChEMBL Target	CHEMBL5790 (Hs)
Ensembl Gene	ENSG00000059758 (Hs), ENSMUSG00000020015 (Mm), ENSRNOG00000004148 (Rn)
Entrez Gene	5128 (Hs), 237459 (Mm), 314743 (Rn)
Human Protein Atlas	ENSG00000059758 (Hs)
KEGG Enzyme	2.7.11.22
KEGG Gene	hsa:5128 (Hs), mmu:237459 (Mm), rno:314743 (Rn)
OMIM	603440 (Hs)
Pharos	Q00537 (Hs)
RefSeq Nucleotide	NM_001170464 (Hs), NM_146239 (Mm), NM_001108082 (Rn)
RefSeq Protein	NP_002586 (Hs), NP_666351 (Mm), NP_001101552 (Rn)
UniProtKB	Q00537 (Hs), Q8K0D0 (Mm), O35831 (Rn)
Wikipedia	CDK17 (Hs)

Enzyme Reaction
EC Number: 2.7.11.22

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1-2
Key to terms and symbols		Click column headers to sort
Target used in screen: PCTK2
Ligand Sp. Type Action Value Parameter R547 Hs Inhibitor Inhibition 9.1 pKd AT-7519 Hs Inhibitor Inhibition 9.0 pKd BMS-387032 Hs Inhibitor Inhibition 7.9 pKd AST-487 Hs Inhibitor Inhibition 7.8 pKd staurosporine Hs Inhibitor Inhibition 7.0 pKd foretinib Hs Inhibitor Inhibition 6.8 pKd tamatinib Hs Inhibitor Inhibition 6.5 pKd fedratinib Hs Inhibitor Inhibition 6.5 pKd alvocidib Hs Inhibitor Inhibition 6.3 pKd lestaurtinib Hs Inhibitor Inhibition 6.1 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »