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Target not currently curated in GtoImmuPdb
Target id: 1971
Nomenclature: cyclin dependent kinase 18
Abbreviated Name: CDK18
Family: TAIRE subfamily
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 474 | 1q32.1 | CDK18 | cyclin dependent kinase 18 | |
Mouse | - | 451 | 1 E4 | Cdk18 | cyclin dependent kinase 18 | |
Rat | - | 451 | 13q13 | Cdk18 | cyclin-dependent kinase 18 |
Previous and Unofficial Names |
cell division protein kinase 18 | PCTAIRE protein kinase 3 | PCTAIRE3 |
Database Links | |
Alphafold | Q07002 (Hs), Q04899 (Mm), O35832 (Rn) |
BRENDA | 2.7.11.22 |
ChEMBL Target | CHEMBL5316 (Hs) |
Ensembl Gene | ENSG00000117266 (Hs), ENSMUSG00000026437 (Mm), ENSRNOG00000008137 (Rn) |
Entrez Gene | 5129 (Hs), 18557 (Mm), 289019 (Rn) |
Human Protein Atlas | ENSG00000117266 (Hs) |
KEGG Enzyme | 2.7.11.22 |
KEGG Gene | hsa:5129 (Hs), mmu:18557 (Mm), rno:289019 (Rn) |
OMIM | 169190 (Hs) |
Pharos | Q07002 (Hs) |
RefSeq Nucleotide | NM_002596 (Hs), NM_008795 (Mm), NM_001100506 (Rn) |
RefSeq Protein | NP_002587 (Hs), NP_032821 (Mm), NP_001093976 (Rn) |
UniProtKB | Q07002 (Hs), Q04899 (Mm), O35832 (Rn) |
Wikipedia | CDK18 (Hs) |
Enzyme Reaction | ||||
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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Inhibitor Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||
CDK18 activity is completely inhibited in the presence of 1μM compound 77 [PMID 24793884] [2] (note that CDK18 is referred to by its synonym PCTK3 in the article's Supplementary data table). |
DiscoveRx KINOMEscan® screen | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1,3 |
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Target used in screen: PCTK3 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]
2. Reichelt A, Bailis JM, Bartberger MD, Yao G, Shu H, Kaller MR, Allen JG, Weidner MF, Keegan KS, Dao JH. (2014) Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors. Eur J Med Chem, 80: 364-82. [PMID:24793884]
3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]
TAIRE subfamily: cyclin dependent kinase 18. Last modified on 25/02/2015. Accessed on 10/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1971.