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Target not currently curated in GtoImmuPdb
Target id: 1983
Nomenclature: cyclin dependent kinase like 2
Abbreviated Name: CdkL2
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 493 | 4q21.1 | CDKL2 | cyclin dependent kinase like 2 | |
Mouse | - | 568 | 5 E2 | Cdkl2 | cyclin dependent kinase like 2 | |
Rat | - | 507 | 14p22 | Cdkl2 | cyclin dependent kinase like 2 |
Previous and Unofficial Names |
KKIAMRE | Kkm | P56 | cyclin-dependent kinase-like 2 (CDC2-related kinase) |
Database Links | |
Alphafold | Q92772 (Hs), Q9QUK0 (Mm), Q5XIT0 (Rn) |
BRENDA | 2.7.11.22 |
ChEMBL Target | CHEMBL5728 (Hs) |
Ensembl Gene | ENSG00000138769 (Hs), ENSMUSG00000029403 (Mm), ENSRNOG00000002506 (Rn) |
Entrez Gene | 8999 (Hs), 53886 (Mm), 305242 (Rn) |
Human Protein Atlas | ENSG00000138769 (Hs) |
KEGG Enzyme | 2.7.11.22 |
KEGG Gene | hsa:8999 (Hs), mmu:53886 (Mm), rno:305242 (Rn) |
OMIM | 603442 (Hs) |
Pharos | Q92772 (Hs) |
RefSeq Nucleotide | NM_003948 (Hs), NM_016912 (Mm), NM_001012035 (Rn) |
RefSeq Protein | NP_003939 (Hs), NP_058608 (Mm), NP_001012035 (Rn) |
UniProtKB | Q92772 (Hs), Q9QUK0 (Mm), Q5XIT0 (Rn) |
Wikipedia | CDKL2 (Hs) |
Enzyme Reaction | ||||
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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Inhibitor Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||
CDKL2 activity is inhibited by >90% in the presence of 1μM URMC-099 [2]. |
DiscoveRx KINOMEscan® screen | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1,3 |
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Target used in screen: CDKL2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]
2. Goodfellow VS, Loweth CJ, Ravula SB, Wiemann T, Nguyen T, Xu Y, Todd DE, Sheppard D, Pollack S, Polesskaya O et al.. (2013) Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem, 56 (20): 8032-48. [PMID:24044867]
3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]
Cyclin-dependent kinase-like (CDKL) family: cyclin dependent kinase like 2. Last modified on 29/01/2016. Accessed on 07/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1983.