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Target not currently curated in GtoImmuPdb
Target id: 2012
Nomenclature: dual specificity tyrosine phosphorylation regulated kinase 3
Abbreviated Name: DYRK3
Family: Dyrk2 subfamily
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 588 | 1q32.1 | DYRK3 | dual specificity tyrosine phosphorylation regulated kinase 3 | |
Mouse | - | 586 | 1 E4 | Dyrk3 | dual-specificity tyrosine phosphorylation regulated kinase 3 | |
Rat | - | 586 | 13q13 | Dyrk3 | dual specificity tyrosine phosphorylation regulated kinase 3 |
Previous and Unofficial Names |
REDK | regulatory erythroid kinase | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 |
Database Links | |
Alphafold | O43781 (Hs), Q922Y0 (Mm), Q4V8A3 (Rn) |
BRENDA | 2.7.12.1 |
ChEMBL Target | CHEMBL4575 (Hs) |
Ensembl Gene | ENSG00000143479 (Hs), ENSMUSG00000016526 (Mm), ENSRNOG00000004870 (Rn) |
Entrez Gene | 8444 (Hs), 226419 (Mm), 304775 (Rn) |
Human Protein Atlas | ENSG00000143479 (Hs) |
KEGG Enzyme | 2.7.12.1 |
KEGG Gene | hsa:8444 (Hs), mmu:226419 (Mm), rno:304775 (Rn) |
OMIM | 603497 (Hs) |
Pharos | O43781 (Hs) |
RefSeq Nucleotide | NM_003582 (Hs), NM_145508 (Mm), NM_001024767 (Rn) |
RefSeq Protein | NP_003573 (Hs), NP_663483 (Mm), NP_001019938 (Rn) |
UniProtKB | O43781 (Hs), Q922Y0 (Mm), Q4V8A3 (Rn) |
Wikipedia | DYRK3 (Hs) |
Enzyme Reaction | ||||
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: ...1 |
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Key to terms and symbols | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Target used in screen: nd/DYRK3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
Immuno Process Associations | ||
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1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1039-45. [PMID:22037377]
2. Burgy G, Tahtouh T, Durieu E, Foll-Josselin B, Limanton E, Meijer L, Carreaux F, Bazureau JP. (2013) Chemical synthesis and biological validation of immobilized protein kinase inhibitory Leucettines. Eur J Med Chem, 62: 728-37. [PMID:23454515]
3. Compain G, Oumata N, Clarhaut J, Péraudeau E, Renoux B, Galons H, Papot S. (2018) A β-glucuronidase-responsive albumin-binding prodrug for potential selective kinase inhibitor-based cancer chemotherapy. Eur J Med Chem, 158: 1-6. [PMID:30199702]
4. Dowling JE, Alimzhanov M, Bao L, Block MH, Chuaqui C, Cooke EL, Denz CR, Hird A, Huang S, Larsen NA et al.. (2013) Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo. ACS Med Chem Lett, 4 (8): 800-5. [PMID:24900749]
5. Riggs JR, Elsner J, Cashion D, Robinson D, Tehrani L, Nagy M, Fultz KE, Krishna Narla R, Peng X, Tran T et al.. (2019) Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy. J Med Chem, 62 (9): 4401-4410. [PMID:30998356]
Dyrk2 subfamily: dual specificity tyrosine phosphorylation regulated kinase 3. Last modified on 02/05/2019. Accessed on 04/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2012.