Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	1313	Xp22.12	MAP3K15	mitogen-activated protein kinase kinase kinase 15
Mouse	-	1331	X F4	Map3k15	mitogen-activated protein kinase kinase kinase 15
Rat	-	-	Xq21	Map3k15	mitogen-activated protein kinase kinase kinase 15

Previous and Unofficial Names

apoptosis signal-regulating kinase 3 | ASK3

Database Links
Alphafold	Q6ZN16 (Hs), A2AQW0 (Mm)
BRENDA	2.7.11.25
ChEMBL Target	CHEMBL1163127 (Hs)
Ensembl Gene	ENSG00000180815 (Hs), ENSMUSG00000031303 (Mm), ENSRNOG00000025290 (Rn)
Entrez Gene	389840 (Hs), 270672 (Mm), 501558 (Rn)
Human Protein Atlas	ENSG00000180815 (Hs)
KEGG Enzyme	2.7.11.25
KEGG Gene	hsa:389840 (Hs), mmu:270672 (Mm), rno:501558 (Rn)
OMIM	300820 (Hs)
Pharos	Q6ZN16 (Hs)
RefSeq Nucleotide	NM_001001671 (Hs), NM_001163085 (Mm)
RefSeq Protein	NP_001001671 (Hs), NP_001156557 (Mm)
UniProtKB	Q6ZN16 (Hs), A2AQW0 (Mm)
Wikipedia	MAP3K15 (Hs)

Enzyme Reaction
EC Number: 2.7.11.25

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1-2
Key to terms and symbols		Click column headers to sort
Target used in screen: MAP3K15
Ligand Sp. Type Action Value Parameter staurosporine Hs Inhibitor Inhibition 8.6 pKd lestaurtinib Hs Inhibitor Inhibition 8.5 pKd NVP-TAE684 Hs Inhibitor Inhibition 6.1 pKd ruxolitinib Hs Inhibitor Inhibition 6.0 pKd SU-14813 Hs Inhibitor Inhibition 5.9 pKd sunitinib Hs Inhibitor Inhibition 5.9 pKd JNJ-28312141 Hs Inhibitor Inhibition 5.6 pKd crizotinib Hs Inhibitor Inhibition 5.6 pKd SB203580 Hs Inhibitor Inhibition <5.5 pKd ruboxistaurin Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »