Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	619	2q14.3	MAP3K2	mitogen-activated protein kinase kinase kinase 2
Mouse	-	619	18 B1	Map3k2	mitogen-activated protein kinase kinase kinase 2
Rat	-	619	18 p12	Map3k2	mitogen activated protein kinase kinase kinase 2

Previous and Unofficial Names

MAP/ERK kinase kinase 2 | MAPKKK2 | MEK kinase 2

Database Links
Alphafold	Q9Y2U5 (Hs), Q61083 (Mm)
BRENDA	2.7.11.25
ChEMBL Target	CHEMBL5914 (Hs)
Ensembl Gene	ENSG00000169967 (Hs), ENSMUSG00000024383 (Mm), ENSRNOG00000014089 (Rn)
Entrez Gene	10746 (Hs), 26405 (Mm), 171492 (Rn)
Human Protein Atlas	ENSG00000169967 (Hs)
KEGG Enzyme	2.7.11.25
KEGG Gene	hsa:10746 (Hs), mmu:26405 (Mm), rno:171492 (Rn)
OMIM	609487 (Hs)
Pharos	Q9Y2U5 (Hs)
RefSeq Nucleotide	NM_006609 (Hs), NM_011946 (Mm), NM_138503 (Rn)
RefSeq Protein	NP_006600 (Hs), NP_036076 (Mm), NP_612512 (Rn)
UniProtKB	Q9Y2U5 (Hs), Q61083 (Mm)
Wikipedia	MAP3K2 (Hs)

Selected 3D Structures
	Description:  Crystal Structure of the complex of human mitogen activated protein kinase kinase 5 phox domain (MAP2K5-phox) with human mitogen activated protein kinase kinase kinase 2 phox domain (MAP3K2-phox) PDB Id:  2NPT Resolution:  1.75Å Species:  Human References:

Enzyme Reaction
EC Number: 2.7.11.25

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference URMC-099 Hs Inhibition 6.2 pIC50 3 ⤷ pIC50 6.2 (IC50 6.61x10-7 M) [3]

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 2,4
Key to terms and symbols		Click column headers to sort
Target used in screen: MAP3K2
Ligand Sp. Type Action Value Parameter staurosporine Hs Inhibitor Inhibition 8.6 pKd lestaurtinib Hs Inhibitor Inhibition 8.3 pKd bosutinib Hs Inhibitor Inhibition 7.5 pKd ruxolitinib Hs Inhibitor Inhibition 7.4 pKd sunitinib Hs Inhibitor Inhibition 7.2 pKd dovitinib Hs Inhibitor Inhibition 7.2 pKd KW-2449 Hs Inhibitor Inhibition 7.1 pKd crizotinib Hs Inhibitor Inhibition 7.1 pKd SU-14813 Hs Inhibitor Inhibition 7.1 pKd JNJ-28312141 Hs Inhibitor Inhibition 7.1 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: ...1
Key to terms and symbols		Click column headers to sort
Target used in screen: nd/MEKK2
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM Cdk1/2 inhibitor III Hs Inhibitor Inhibition -0.5 staurosporine Hs Inhibitor Inhibition 1.2 K-252a Hs Inhibitor Inhibition 2.9 Gö 6976 Hs Inhibitor Inhibition 3.0 JNJ-7706621 Hs Inhibitor Inhibition 11.3 SB 218078 Hs Inhibitor Inhibition 14.0 SU11652 Hs Inhibitor Inhibition 20.1 bosutinib Hs Inhibitor Inhibition 23.5 Cdk2 inhibitor IV Hs Inhibitor Inhibition 25.3 midostaurin Hs Inhibitor Inhibition 30.2
Displaying the top 10 most potent ligands  View all ligands in screen »