Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	1608	6q26	MAP3K4	mitogen-activated protein kinase kinase kinase 4
Mouse	-	1597	17 A1	Map3k4	mitogen-activated protein kinase kinase kinase 4
Rat	-	1387	1 q11	Map3k4	mitogen activated protein kinase kinase kinase 4

Previous and Unofficial Names

MAP three kinase 1 | MAPK/ERK kinase kinase 4 | MAPKKK4 | MTK1 | RP17 | Tas

Database Links
Alphafold	Q9Y6R4 (Hs), O08648 (Mm)
BRENDA	2.7.11.25
ChEMBL Target	CHEMBL4853 (Hs)
Ensembl Gene	ENSG00000085511 (Hs), ENSMUSG00000014426 (Mm), ENSRNOG00000017419 (Rn)
Entrez Gene	4216 (Hs), 26407 (Mm), 308106 (Rn)
Human Protein Atlas	ENSG00000085511 (Hs)
KEGG Enzyme	2.7.11.25
KEGG Gene	hsa:4216 (Hs), mmu:26407 (Mm), rno:308106 (Rn)
OMIM	602425 (Hs)
Pharos	Q9Y6R4 (Hs)
RefSeq Nucleotide	NM_005922 (Hs), NM_011948 (Mm), NM_001107456 (Rn)
RefSeq Protein	NP_005913 (Hs), NP_036078 (Mm), NP_001100926 (Rn)
UniProtKB	Q9Y6R4 (Hs), O08648 (Mm)
Wikipedia	MAP3K4 (Hs)

Enzyme Reaction
EC Number: 2.7.11.25

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1-2
Key to terms and symbols		Click column headers to sort
Target used in screen: MAP3K4
Ligand Sp. Type Action Value Parameter neratinib Hs Inhibitor Inhibition 7.4 pKd PD-173955 Hs Inhibitor Inhibition 7.3 pKd bosutinib Hs Inhibitor Inhibition 7.0 pKd dasatinib Hs Inhibitor Inhibition 6.5 pKd tamatinib Hs Inhibitor Inhibition 6.1 pKd staurosporine Hs Inhibitor Inhibition 5.9 pKd KW-2449 Hs Inhibitor Inhibition 5.8 pKd PHA-665752 Hs Inhibitor Inhibition 5.7 pKd foretinib Hs Inhibitor Inhibition 5.7 pKd NVP-TAE684 Hs Inhibitor Inhibition 5.7 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »