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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 1616 | 10p12.1 | MYO3A | myosin IIIA | |
Mouse | - | 1613 | 2 A3 | Myo3a | myosin IIIA | |
Rat | - | 1620 | 17q12.3 | Myo3a | myosin IIIA |
Previous and Unofficial Names ![]() |
DFNB30 |
Database Links ![]() |
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Alphafold | Q8NEV4 (Hs), Q8K3H5 (Mm) |
BRENDA | 2.7.11.1 |
ChEMBL Target | CHEMBL5546 (Hs) |
Ensembl Gene | ENSG00000095777 (Hs), ENSMUSG00000025716 (Mm), ENSRNOG00000018478 (Rn) |
Entrez Gene | 53904 (Hs), 667663 (Mm), 498806 (Rn) |
Human Protein Atlas | ENSG00000095777 (Hs) |
KEGG Enzyme | 2.7.11.1 |
KEGG Gene | hsa:53904 (Hs), mmu:667663 (Mm), rno:498806 (Rn) |
OMIM | 606808 (Hs) |
Orphanet | ORPHA160313 (Hs) |
Pharos | Q8NEV4 (Hs) |
RefSeq Nucleotide | NM_017433 (Hs), NM_148413 (Mm), XM_001053631 (Rn) |
RefSeq Protein | NP_059129 (Hs), NP_680779 (Mm), XP_001053631 (Rn) |
UniProtKB | Q8NEV4 (Hs), Q8K3H5 (Mm) |
Wikipedia | MYO3A (Hs) |
Enzyme Reaction ![]() |
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DiscoveRx KINOMEscan® screen ![]() |
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A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1-2 |
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Target used in screen: MYO3A | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
Clinically-Relevant Mutations and Pathophysiology ![]() |
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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]
2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]
NinaC subfamily: myosin IIIA. Last modified on 18/08/2014. Accessed on 17/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2112.