Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	1341	2q31.1	MYO3B	myosin IIIB
Mouse	-	1305	2 C2	Myo3b	myosin IIIB
Rat	-	1299	3q21	Myo3b	myosin IIIB

Database Links
Alphafold	Q8WXR4 (Hs), Q1EG27 (Mm)
BRENDA	2.7.11.1
ChEMBL Target	CHEMBL5654 (Hs)
Ensembl Gene	ENSG00000071909 (Hs), ENSMUSG00000042064 (Mm), ENSRNOG00000030022 (Rn)
Entrez Gene	140469 (Hs), 329421 (Mm), 366069 (Rn)
Human Protein Atlas	ENSG00000071909 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:140469 (Hs), mmu:329421 (Mm), rno:366069 (Rn)
OMIM	610040 (Hs)
Pharos	Q8WXR4 (Hs)
RefSeq Nucleotide	NM_001171642 (Hs), NM_001042509 (Mm), NM_001191901 (Rn)
RefSeq Protein	NP_001077084 (Hs), NP_796350 (Mm), NP_001178830 (Rn)
UniProtKB	Q8WXR4 (Hs), Q1EG27 (Mm)
Wikipedia	MYO3B (Hs)

Enzyme Reaction
EC Number: 2.7.11.1

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 2-3
Key to terms and symbols		Click column headers to sort
Target used in screen: MYO3B
Ligand Sp. Type Action Value Parameter NVP-TAE684 Hs Inhibitor Inhibition 7.1 pKd AST-487 Hs Inhibitor Inhibition 7.1 pKd staurosporine Hs Inhibitor Inhibition 6.5 pKd foretinib Hs Inhibitor Inhibition 6.2 pKd lestaurtinib Hs Inhibitor Inhibition 6.1 pKd PP-242 Hs Inhibitor Inhibition 5.7 pKd bosutinib Hs Inhibitor Inhibition 5.6 pKd SB203580 Hs Inhibitor Inhibition <5.5 pKd ruboxistaurin Hs Inhibitor Inhibition <5.5 pKd erlotinib Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: ...1
Key to terms and symbols		Click column headers to sort
Target used in screen: nd/MYO3b
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM staurosporine Hs Inhibitor Inhibition 2.8 K-252a Hs Inhibitor Inhibition 4.5 PKR inhibitor, negative control Hs Inhibitor Inhibition 17.4 SB 218078 Hs Inhibitor Inhibition 19.1 PKR inhibitor Hs Inhibitor Inhibition 30.9 PKCbeta inhibitor Hs Inhibitor Inhibition 36.0 bosutinib Hs Inhibitor Inhibition 40.3 SU11652 Hs Inhibitor Inhibition 41.3 JAK3 inhibitor VI Hs Inhibitor Inhibition 50.9 midostaurin Hs Inhibitor Inhibition 53.7
Displaying the top 10 most potent ligands  View all ligands in screen »