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Target not currently curated in GtoImmuPdb
Target id: 2143
Nomenclature: pyruvate dehydrogenase kinase 3
Abbreviated Name: PDHK3
Family: PDHK family
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 406 | Xp22.11 | PDK3 | pyruvate dehydrogenase kinase 3 | |
Mouse | - | 415 | X C3 | Pdk3 | pyruvate dehydrogenase kinase, isoenzyme 3 | |
Rat | - | 415 | X q22 | Pdk3 | pyruvate dehydrogenase kinase 3 |
Previous and Unofficial Names ![]() |
pyruvate dehydrogenase kinase, isozyme 3 | pyruvate dehydrogenase kinase |
Database Links ![]() |
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Alphafold | Q15120 (Hs), Q922H2 (Mm) |
BRENDA | 2.7.11.2 |
CATH/Gene3D | 1.20.140.20, 3.30.565.10 |
ChEMBL Target | CHEMBL3893 (Hs) |
Ensembl Gene | ENSG00000067992 (Hs), ENSMUSG00000035232 (Mm), ENSRNOG00000012513 (Rn) |
Entrez Gene | 5165 (Hs), 236900 (Mm), 296849 (Rn) |
Human Protein Atlas | ENSG00000067992 (Hs) |
KEGG Enzyme | 2.7.11.2 |
KEGG Gene | hsa:5165 (Hs), mmu:236900 (Mm), rno:296849 (Rn) |
OMIM | 602526 (Hs) |
Orphanet | ORPHA356172 (Hs) |
Pharos | Q15120 (Hs) |
RefSeq Nucleotide | NM_001142386 (Hs), NM_145630 (Mm), NM_001106581 (Rn) |
RefSeq Protein | NP_001135858 (Hs), NP_663605 (Mm), NP_001100051 (Rn) |
UniProtKB | Q15120 (Hs), Q922H2 (Mm) |
Wikipedia | PDK3 (Hs) |
Selected 3D Structures ![]() |
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Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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Clinically-Relevant Mutations and Pathophysiology ![]() |
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1. Kato M, Chuang JL, Tso SC, Wynn RM, Chuang DT. (2005) Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex. EMBO J, 24 (10): 1763-74. [PMID:15861126]
2. Moore JD, Staniszewska A, Shaw T, D'Alessandro J, Davis B, Surgenor A, Baker L, Matassova N, Murray J, Macias A et al.. (2014) VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Oncotarget, 5 (24): 12862-76. [PMID:25404640]
PDHK family: pyruvate dehydrogenase kinase 3. Last modified on 03/11/2016. Accessed on 15/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2143.