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Target not currently curated in GtoImmuPdb
Target id: 2144
Nomenclature: pyruvate dehydrogenase kinase 4
Abbreviated Name: LOC389533
Family: PDHK family
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 411 | 7q21.3 | PDK4 | pyruvate dehydrogenase kinase 4 | |
Mouse | - | 412 | 6 2.06 cM | Pdk4 | pyruvate dehydrogenase kinase, isoenzyme 4 | |
Rat | - | 412 | 4q13 | Pdk4 | pyruvate dehydrogenase kinase 4 |
Previous and Unofficial Names ![]() |
pyruvate dehydrogenase kinase, isozyme 4 | pyruvate dehydrogenase kinase |
Database Links ![]() |
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Alphafold | Q16654 (Hs), O70571 (Mm), O54937 (Rn) |
BRENDA | 2.7.11.2 |
CATH/Gene3D | 1.20.140.20, 3.30.565.10 |
ChEMBL Target | CHEMBL4141 (Hs) |
Ensembl Gene | ENSG00000004799 (Hs), ENSMUSG00000019577 (Mm), ENSRNOG00000009565 (Rn) |
Entrez Gene | 5166 (Hs), 27273 (Mm), 89813 (Rn) |
Human Protein Atlas | ENSG00000004799 (Hs) |
KEGG Enzyme | 2.7.11.2 |
KEGG Gene | hsa:5166 (Hs), mmu:27273 (Mm), rno:89813 (Rn) |
OMIM | 602527 (Hs) |
Pharos | Q16654 (Hs) |
RefSeq Nucleotide | NM_002612 (Hs), NM_013743 (Mm), NM_053551 (Rn) |
RefSeq Protein | NP_002603 (Hs), NP_038771 (Mm), NP_446003 (Rn) |
UniProtKB | Q16654 (Hs), O70571 (Mm), O54937 (Rn) |
Wikipedia | PDK4 (Hs) |
Selected 3D Structures ![]() |
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Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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1. Kukimoto-Niino M, Tokmakov A, Terada T, Ohbayashi N, Fujimoto T, Gomi S, Shiromizu I, Kawamoto M, Matsusue T, Shirouzu M et al.. (2011) Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4. Acta Crystallogr D Biol Crystallogr, 67 (Pt 9): 763-73. [PMID:21904029]
2. Moore JD, Staniszewska A, Shaw T, D'Alessandro J, Davis B, Surgenor A, Baker L, Matassova N, Murray J, Macias A et al.. (2014) VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Oncotarget, 5 (24): 12862-76. [PMID:25404640]
PDHK family: pyruvate dehydrogenase kinase 4. Last modified on 03/11/2016. Accessed on 15/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2144.