Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	552	5q15	RIOK2	RIO kinase 2
Mouse	-	547	17 A3.1	Riok2	RIO kinase 2
Rat	-	551	1q12	Riok2	RIO kinase 2

Database Links
Alphafold	Q9BVS4 (Hs), Q9CQS5 (Mm), Q5I0I1 (Rn)
BRENDA	2.7.11.1
CATH/Gene3D	1.10.10.10
ChEMBL Target	CHEMBL6000 (Hs)
Ensembl Gene	ENSG00000058729 (Hs), ENSMUSG00000116564 (Mm), ENSRNOG00000012692 (Rn)
Entrez Gene	55781 (Hs), 67045 (Mm), 308201 (Rn)
Human Protein Atlas	ENSG00000058729 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:55781 (Hs), mmu:67045 (Mm), rno:308201 (Rn)
Pharos	Q9BVS4 (Hs)
RefSeq Nucleotide	NM_018343 (Hs), NM_025934 (Mm), NM_001009687 (Rn)
RefSeq Protein	NP_060813 (Hs), NP_080210 (Mm), NP_001009687 (Rn)
UniProtKB	Q9BVS4 (Hs), Q9CQS5 (Mm), Q5I0I1 (Rn)
Wikipedia	RIOK2 (Hs)

Enzyme Reaction
EC Number: 2.7.11.1

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1-2
Key to terms and symbols		Click column headers to sort
Target used in screen: RIOK2
Ligand Sp. Type Action Value Parameter sunitinib Hs Inhibitor Inhibition 7.3 pKd midostaurin Hs Inhibitor Inhibition 7.0 pKd SU-14813 Hs Inhibitor Inhibition 6.8 pKd tozasertib Hs Inhibitor Inhibition 6.6 pKd dovitinib Hs Inhibitor Inhibition 6.6 pKd staurosporine Hs Inhibitor Inhibition 6.4 pKd AST-487 Hs Inhibitor Inhibition 6.3 pKd pazopanib Hs Inhibitor Inhibition 6.2 pKd pictilisib Hs Inhibitor Inhibition 6.2 pKd PI-103 Hs Inhibitor Inhibition 6.1 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »