SH3 domain binding kinase 1 | NKF1 family | IUPHAR/BPS Guide to PHARMACOLOGY

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SH3 domain binding kinase 1

Target not currently curated in GtoImmuPdb

Target id: 2193

Nomenclature: SH3 domain binding kinase 1

Abbreviated Name: SBK

Family: NKF1 family

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 424 16p11.2 SBK1 SH3 domain binding kinase 1
Mouse - 417 7 F1-F3 Sbk1 SH3-binding kinase 1
Rat - 417 1 q21.3 Sbk1 SH3 domain binding kinase 1
Previous and Unofficial Names
SH3-binding domain kinase 1
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: SBK1
Ligand Sp. Type Action Value Parameter
staurosporine Hs Inhibitor Inhibition 8.5 pKd
NVP-TAE684 Hs Inhibitor Inhibition 7.7 pKd
tamatinib Hs Inhibitor Inhibition 7.0 pKd
sunitinib Hs Inhibitor Inhibition 6.7 pKd
lestaurtinib Hs Inhibitor Inhibition 6.7 pKd
gefitinib Hs Inhibitor Inhibition 6.3 pKd
KW-2449 Hs Inhibitor Inhibition 6.2 pKd
SU-14813 Hs Inhibitor Inhibition 6.2 pKd
fedratinib Hs Inhibitor Inhibition 6.1 pKd
dasatinib Hs Inhibitor Inhibition 5.9 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

NKF1 family: SH3 domain binding kinase 1. Last modified on 21/03/2013. Accessed on 25/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2193.