testis associated actin remodelling kinase 2 | TESK subfamily | IUPHAR/BPS Guide to PHARMACOLOGY

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testis associated actin remodelling kinase 2

Target not currently curated in GtoImmuPdb

Target id: 2240

Nomenclature: testis associated actin remodelling kinase 2

Abbreviated Name: TESK2

Family: TESK subfamily

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 571 1p32 TESK2 testis associated actin remodelling kinase 2
Mouse - 570 4 D1 Tesk2 testis-specific kinase 2
Rat - 570 5 q36 Tesk2 testis associated actin remodelling kinase 2
Previous and Unofficial Names
dual specificity testis-specific protein kinase 2 | testicular protein kinase 2
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.12.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 31 [PMID: 22902653] Hs Inhibition 6.6 pIC50 1
pIC50 6.6 (IC50 2.52x10-7 M) [1]
compound 30 [PMID: 22902653] Hs Inhibition 6.4 pIC50 1
pIC50 6.4 (IC50 4.15x10-7 M) [1]
compound 35 [PMID: 22902653] Hs Inhibition <4.5 pIC50 1
pIC50 <4.5 (IC50 >3x10-5 M) [1]

References

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1. He L, Seitz SP, Trainor GL, Tortolani D, Vaccaro W, Poss M, Tarby CM, Tokarski JS, Penhallow B, Hung CY et al.. (2012) Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg. Med. Chem. Lett., 22 (18): 5995-8. [PMID:22902653]

How to cite this page

TESK subfamily: testis associated actin remodelling kinase 2. Last modified on 09/05/2018. Accessed on 26/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2240.