Top ▲

testis associated actin remodelling kinase 2

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 2240

Nomenclature: testis associated actin remodelling kinase 2

Abbreviated Name: TESK2

Family: TESK subfamily

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 571 1p34.1 TESK2 testis associated actin remodelling kinase 2
Mouse - 570 4 D1 Tesk2 testis-specific kinase 2
Rat - 570 5q35 Tesk2 testis associated actin remodelling kinase 2
Previous and Unofficial Names Click here for help
dual specificity testis-specific protein kinase 2 | testicular protein kinase 2
Database Links Click here for help
Alphafold
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 2.7.12.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 31 [PMID: 22902653] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.6 pIC50 1
pIC50 6.6 (IC50 2.52x10-7 M) [1]
compound 30 [PMID: 22902653] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.4 pIC50 1
pIC50 6.4 (IC50 4.15x10-7 M) [1]
compound 35 [PMID: 22902653] Small molecule or natural product Click here for species-specific activity table Hs Inhibition <4.5 pIC50 1
pIC50 <4.5 (IC50 >3x10-5 M) [1]

References

Show »

1. He L, Seitz SP, Trainor GL, Tortolani D, Vaccaro W, Poss M, Tarby CM, Tokarski JS, Penhallow B, Hung CY et al.. (2012) Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett, 22 (18): 5995-8. [PMID:22902653]

How to cite this page

TESK subfamily: testis associated actin remodelling kinase 2. Last modified on 09/05/2018. Accessed on 25/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2240.