TNNI3 interacting kinase | HH498 subfamily | IUPHAR/BPS Guide to PHARMACOLOGY

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TNNI3 interacting kinase

Target not currently curated in GtoImmuPdb

Target id: 2247

Nomenclature: TNNI3 interacting kinase

Abbreviated Name: HH498

Family: HH498 subfamily

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 835 1p31.1 TNNI3K TNNI3 interacting kinase
Mouse - 834 3 Tnni3k TNNI3 interacting kinase
Rat - 835 2q45 Tnni3k TNNI3 interacting kinase
Previous and Unofficial Names
cardiac ankyrin repeat kinase | Cark
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: TNNI3K
Ligand Sp. Type Action Value Parameter
dasatinib Hs Inhibitor Inhibition 8.0 pKd
PD-173955 Hs Inhibitor Inhibition 7.3 pKd
alvocidib Hs Inhibitor Inhibition 7.3 pKd
crizotinib Hs Inhibitor Inhibition 7.0 pKd
foretinib Hs Inhibitor Inhibition 6.9 pKd
bosutinib Hs Inhibitor Inhibition 6.8 pKd
AST-487 Hs Inhibitor Inhibition 6.8 pKd
motesanib Hs Inhibitor Inhibition 6.7 pKd
sorafenib Hs Inhibitor Inhibition 6.6 pKd
tamatinib Hs Inhibitor Inhibition 6.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »
Clinically-Relevant Mutations and Pathophysiology
Disease:  Cardiac conduction disease with or without dilated cardiomyopathy; CCDD
OMIM: 616117

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

HH498 subfamily: TNNI3 interacting kinase. Last modified on 06/05/2015. Accessed on 26/06/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2247.