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Target not currently curated in GtoImmuPdb
Target id: 2258
Nomenclature: testis specific serine kinase 2
Abbreviated Name: TSSK2
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 358 | 22q11.21 | TSSK2 | testis specific serine kinase 2 | |
Mouse | - | 358 | 16 11.09 cM | Tssk2 | testis-specific serine kinase 2 | |
Rat | - | 358 | 11 q23 | Tssk2 | testis-specific serine kinase 2 |
Previous and Unofficial Names ![]() |
serine/threonine kinase 22B (spermiogenesis associated) | SPOGA2 | STK22B | Tsk2 |
Database Links ![]() |
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Alphafold | Q96PF2 (Hs), O54863 (Mm) |
BRENDA | 2.7.11.1 |
ChEMBL Target | CHEMBL6014 (Hs) |
Ensembl Gene | ENSG00000206203 (Hs), ENSMUSG00000045521 (Mm), ENSRNOG00000037997 (Rn) |
Entrez Gene | 23617 (Hs), 22115 (Mm), 304181 (Rn) |
Human Protein Atlas | ENSG00000206203 (Hs) |
KEGG Enzyme | 2.7.11.1 |
KEGG Gene | hsa:23617 (Hs), mmu:22115 (Mm), rno:304181 (Rn) |
OMIM | 610710 (Hs) |
Pharos | Q96PF2 (Hs) |
RefSeq Nucleotide | NM_053006 (Hs), NM_009436 (Mm), NM_001012019 (Rn) |
RefSeq Protein | NP_443732 (Hs), NP_033462 (Mm), NP_001012019 (Rn) |
UniProtKB | Q96PF2 (Hs), O54863 (Mm) |
Wikipedia | TSSK2 (Hs) |
Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen ![]() |
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A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: 1-2 |
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Target used in screen: TSSK2/TSSK2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1039-45. [PMID:22037377]
2. Gao Y, Davies SP, Augustin M, Woodward A, Patel UA, Kovelman R, Harvey KJ. (2013) A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. Biochem J, 451 (2): 313-28. [PMID:23398362]
3. Wang T, Lamb ML, Block MH, Davies AM, Han Y, Hoffmann E, Ioannidis S, Josey JA, Liu ZY, Lyne PD et al.. (2012) Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors. ACS Med Chem Lett, 3 (9): 705-9. [PMID:24900538]
Testis specific kinase (TSSK) family: testis specific serine kinase 2. Last modified on 29/01/2016. Accessed on 09/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2258.