WEE2 oocyte meiosis inhibiting kinase | WEE family | IUPHAR/BPS Guide to PHARMACOLOGY

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WEE2 oocyte meiosis inhibiting kinase

Target not currently curated in GtoImmuPdb

Target id: 2279

Nomenclature: WEE2 oocyte meiosis inhibiting kinase

Abbreviated Name: WEE1B

Family: WEE family

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 567 7q32 WEE2 WEE2 oocyte meiosis inhibiting kinase
Mouse - 555 6 B1 Wee2 WEE1 homolog 2 (S. pombe)
Rat - - 4q22 Wee2 WEE2 oocyte meiosis inhibiting kinase
Previous and Unofficial Names
WEE1 homolog 2 | wee1-like protein kinase 2
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: WEE2
Ligand Sp. Type Action Value Parameter
PD-173955 Hs Inhibitor Inhibition 7.2 pKd
bosutinib Hs Inhibitor Inhibition 7.0 pKd
dasatinib Hs Inhibitor Inhibition 6.7 pKd
neratinib Hs Inhibitor Inhibition 5.9 pKd
ruboxistaurin Hs Inhibitor Inhibition <5.5 pKd
SB203580 Hs Inhibitor Inhibition <5.5 pKd
erlotinib Hs Inhibitor Inhibition <5.5 pKd
GSK690693 Hs Inhibitor Inhibition <5.5 pKd
masitinib Hs Inhibitor Inhibition <5.5 pKd
A-674563 Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

WEE family: WEE2 oocyte meiosis inhibiting kinase. Last modified on 12/11/2019. Accessed on 26/02/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2279.