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Target not currently curated in GtoImmuPdb
Target id: 2289
Nomenclature: ZAK sterile alpha motif and leucine zipper containing kinase AZK
Abbreviated Name: ZAK
Family: MLK subfamily
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 800 | 2q31.1 | MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | |
Mouse | - | 802 | 2 C3 | Map3k20 | mitogen-activated protein kinase kinase kinase 20 | |
Rat | - | 802 | 3q22 | Map3k20 | mitogen-activated protein kinase kinase kinase 20 |
Database Links ![]() |
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Alphafold | Q9NYL2 (Hs), Q9ESL4 (Mm) |
BRENDA | 2.7.11.25 |
ChEMBL Target | CHEMBL3886 (Hs), CHEMBL4523452 (Mm) |
Ensembl Gene | ENSG00000091436 (Hs), ENSMUSG00000004085 (Mm), ENSRNOG00000001515 (Rn) |
Entrez Gene | 51776 (Hs), 65964 (Mm), 311743 (Rn) |
Human Protein Atlas | ENSG00000091436 (Hs) |
KEGG Enzyme | 2.7.11.25 |
KEGG Gene | hsa:51776 (Hs), mmu:65964 (Mm), rno:311743 (Rn) |
OMIM | 609479 (Hs) |
Pharos | Q9NYL2 (Hs) |
RefSeq Nucleotide | NM_016653 (Hs), NM_023057 (Mm), XM_002729174 (Rn) |
RefSeq Protein | NP_057737 (Hs), NP_075544 (Mm), XP_001059755 (Rn) |
UniProtKB | Q9NYL2 (Hs), Q9ESL4 (Mm) |
Wikipedia | MAP3K20 (Hs) |
Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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DiscoveRx KINOMEscan® screen ![]() |
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A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 2,4 |
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Target used in screen: ZAK | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen ![]() |
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A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: ...1 |
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Target used in screen: nd/ZAK(MLTK) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1039-45. [PMID:22037377]
2. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]
3. Li HY, Wang Y, Heap CR, King CH, Mundla SR, Voss M, Clawson DK, Yan L, Campbell RM, Anderson BD et al.. (2006) Dihydropyrrolopyrazole transforming growth factor-beta type I receptor kinase domain inhibitors: a novel benzimidazole series with selectivity versus transforming growth factor-beta type II receptor kinase and mixed lineage kinase-7. J Med Chem, 49 (6): 2138-42. [PMID:16539403]
4. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]
5. Yang J, Shibu MA, Kong L, Luo J, BadrealamKhan F, Huang Y, Tu ZC, Yun CH, Huang CY, Ding K et al.. (2020) Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors. J Med Chem, 63 (5): 2114-2130. [PMID:31244114]
MLK subfamily: ZAK sterile alpha motif and leucine zipper containing kinase AZK. Last modified on 06/06/2019. Accessed on 11/08/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2289.