sugen kinase 110 | NKF1 family | IUPHAR/BPS Guide to PHARMACOLOGY

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sugen kinase 110

Target not currently curated in GtoImmuPdb

Target id: 2290

Nomenclature: sugen kinase 110

Abbreviated Name: SGK110

Family: NKF1 family

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 359 19q13.42 SGK110 sugen kinase 110
Mouse - 362 7 A1 Sbk3 SH3 domain binding kinase family
Previous and Unofficial Names
SG110 | Gm1078 | predicted gene 1078 | SH3 domain binding kinase family, member 3 | SH3 domain binding kinase family
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound R-16 [PMID: 21967808] Hs Inhibition - - 2
Description: Measured as % inhibition using 1μM compound.
Inhibitor Comments
SGK110 activity is inhibited by 98% in the presence of 1μM compound R-16 [PMID 21967808] [2].
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
Reference: 1,3

Key to terms and symbols Click column headers to sort
Target used in screen: SgK110
Ligand Sp. Type Action Value Parameter
staurosporine Hs Inhibitor Inhibition 7.6 pKd
NVP-TAE684 Hs Inhibitor Inhibition 7.3 pKd
lestaurtinib Hs Inhibitor Inhibition 6.9 pKd
tamatinib Hs Inhibitor Inhibition 6.7 pKd
KW-2449 Hs Inhibitor Inhibition 6.6 pKd
crizotinib Hs Inhibitor Inhibition 6.6 pKd
tozasertib Hs Inhibitor Inhibition 6.3 pKd
PD-173955 Hs Inhibitor Inhibition 6.0 pKd
JNJ-28312141 Hs Inhibitor Inhibition 6.0 pKd
sunitinib Hs Inhibitor Inhibition 5.7 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »


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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Milkiewicz KL, Aimone LD, Albom MS, Angeles TS, Chang H, Grobelny JV, Husten J, Losardo C, Miknyoczki S, Murthy S et al.. (2011) Improvement in oral bioavailability of 2,4-diaminopyrimidine c-Met inhibitors by incorporation of a 3-amidobenzazepin-2-one group. Bioorg. Med. Chem., 19 (21): 6274-84. [PMID:21967808]

3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

NKF1 family: sugen kinase 110. Last modified on 24/02/2015. Accessed on 25/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY,