serine/threonine-protein kinase NIM1 | NIM1 subfamily | IUPHAR/BPS Guide to PHARMACOLOGY

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serine/threonine-protein kinase NIM1

Target not currently curated in GtoImmuPdb

Target id: 2291

Nomenclature: serine/threonine-protein kinase NIM1

Abbreviated Name: NIM1

Family: NIM1 subfamily

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 436 5p12 NIM1K NIM1 serine/threonine protein kinase
Mouse - 436 13 Nim1k NIM1 serine/threonine protein kinase
Rat - 436 2q16 Nim1k NIM1 serine/threonine protein kinase
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 89S [PMID: 19115845] Hs Inhibition <5.4 pIC50 2
pIC50 <5.4 (IC50 >4x10-6 M) [2]
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1,3

Key to terms and symbols Click column headers to sort
Target used in screen: NIM1
Ligand Sp. Type Action Value Parameter
staurosporine Hs Inhibitor Inhibition 6.8 pKd
tamatinib Hs Inhibitor Inhibition 6.2 pKd
BI-2536 Hs Inhibitor Inhibition 6.1 pKd
sunitinib Hs Inhibitor Inhibition 6.1 pKd
dovitinib Hs Inhibitor Inhibition 6.1 pKd
SU-14813 Hs Inhibitor Inhibition 6.0 pKd
KW-2449 Hs Inhibitor Inhibition 6.0 pKd
bosutinib Hs Inhibitor Inhibition 5.8 pKd
lestaurtinib Hs Inhibitor Inhibition 5.7 pKd
NVP-TAE684 Hs Inhibitor Inhibition 5.6 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Menichincheri M, Bargiotti A, Berthelsen J, Bertrand JA, Bossi R, Ciavolella A, Cirla A, Cristiani C, Croci V, D'Alessio R et al.. (2009) First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. J. Med. Chem., 52 (2): 293-307. [PMID:19115845]

3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

NIM1 subfamily: serine/threonine-protein kinase NIM1. Last modified on 17/09/2015. Accessed on 24/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2291.